@article{MRA, author = {Nowreen Haq and Katherine Araque and Anastasia Kanegusuku and Bin Wei and Steven Soldin}, title = { Are serum cortisol measurements by immunoassays reliable?}, journal = {Medical Research Archives}, volume = {8}, number = {5}, year = {2020}, keywords = {}, abstract = {Routinely used automated immunoassays have been found to give unrealiable measurements of thyroid hormones in the presence of either high or low levels of thyroxine-binding globulin. Thyroid hormones are not the only analytes bound to specific binding proteins that are measured by immunoassays. Preliminary data from a series of cases, comparing IA measurements to those obtained by liquid chromatography-tandem mass spectrometry, reveal for the first time that IA measurements report falsely low (by an average of 27%) serum cortisol concentrations. Initial findings suggest that IA measurements of serum cortisol are affected by high concentrations of corticosteroid binding globulin.  }, issn = {2375-1924}, doi = {10.18103/mra.v8i5.2128}, url = {https://esmed.org/MRA/mra/article/view/2128} }