%A Malviya, Sanjana A. %A Bruner, Emily G %A Belfar, Alexandra %A Deng, Yi %D 2021 %T Alternatives to heparin anticoagulation for cardiopulmonary bypass and extracorporeal membrane oxygenation %K %X Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are both mechanical circulatory support technologies that augment the native heart and/or lung function. They involve drainage and reinfusion of blood while performing extracorporeal gas exchange. 1 In both devices, contact between patient blood and the non-endothelialized surface of the circuit triggers an inflammatory response and pro-coagulation cascade. 2–5 As a result, prophylactic anticoagulation is integral to prevent catastrophic thrombosis of the circuitry. In rare instances, there exist contraindications to heparin use, necessitating alternative management strategies. 6 In this review, we will examine heparin contraindications in mechanical circulatory support and summarize alternative approaches to anticoagulation in these circumstances. %U https://esmed.org/MRA/mra/article/view/2528 %J Medical Research Archives %0 Journal Article %R 10.18103/mra.v9i8.2528 %V 9 %N 8 %@ 2375-1924 %8 2021-08-11