@article{MRA, author = {Ana Luisa Fernandes and Natália Melo and Inês Neves and Hélder Novais Bastos and Patrícia Caetano Mota and André Carvalho and José Miguel Pereira and Susana Guimarães and Conceição Souto Moura and António Morais}, title = { Pleuroparenchymal Fibroelastosis and Hypersensitivity Pneumonitis: A Clinical, Radiological and Pathological Overview}, journal = {Medical Research Archives}, volume = {10}, number = {7}, year = {2022}, keywords = {}, abstract = {Non-idiopathic pleuroparenchymal fibroelastosis (PPFE) has been increasingly reported in the literature. Little is known about the clinical relevance of PFFE and hypersensitivity pneumonitis (HP) overlap; therefore, we sought to investigate the clinical, radiological, and pathological features of patients with these two diseases. Five patients were identified, and the detailed characterization of these cases revealed a heterogeneous group in terms of clinical and treatment options. No mortality, acute exacerbations, or a significant decline in lung function were verified. Our cases seem to have a more “benign” disease behavior, contrary to previous idiopathic PPFE studies. More studies are needed to corroborate these findings and to better elucidate the clinical significance of PPFE and HP overlap.}, issn = {2375-1924}, doi = {10.18103/mra.v10i7.2851}, url = {https://esmed.org/MRA/mra/article/view/2851} }