@article{MRA, author = {Tammy Scott and Irwin Rosenberg}, title = { Small Vessel Cerebrovascular Pathology is a Major Feature in the Pathogenesis of Alzheimer’s Disease or Age-Related Dementia}, journal = {Medical Research Archives}, volume = {10}, number = {9}, year = {2022}, keywords = {}, abstract = {Historically, cerebrovascular abnormalities were recognized as prominent in the pathology of age-related dementia. In more recent decades, however, research and funding for development of therapeutics has almost entirely been focused on β-amyloid and tau deposits (as described by Alzheimer in pre-senile dementia), despite a lack of conclusive evidence of a causal relationship or efficacy of targeted treatment on cognitive decline or dementia. Here we present a brief history of the evidence for a dominant vascular component of Alzheimer’s Disease and highlight a potential target for slowing the functional progression of the disease.}, issn = {2375-1924}, doi = {10.18103/mra.v10i9.3139}, url = {https://esmed.org/MRA/mra/article/view/3139} }