%A Mathkhor, Abdulsatar J %A Abdullah, Abdulnasser H %A Atwan, Ali H %A Kamel, Zahraa Mustafa %D 2022 %T Vitamin D Deficiency is Associated with Knee Osteoarthritis and is Implicated in the Osteoarthritis Severity %K %X Background : Levels of Vitamin D may impact the development and progression of knee osteoarthritis (OA), a disorder common in elderly people The aim of this study was to investigate the association between serum Vitamin D deficiency and knee OA. Methods : One hundred twenty (40 male and 80 female) consecutive patients were recruited from the rheumatology outpatient clinic for the study. X-rays in two anterior-posterior and lateral views of the knees were performed for all patients. Staging of knee OA was done according to Kellgren-Lawrence criteria and divided into two groups; group A consisting of grades 1 and 2, and group B, consisting of grades 3 and 4. One hundred (30 male and 70 female) healthy individuals without clinical and radiographic signs of the disease were defined as a control group. Hematological and biochemical investigations, including measurement of 25-hydroxyvitamin D serum level, were performed for all participants. Pain intensity using a visual analog scale (VAS) and disease severity using the Western Ontario and McMaster Universities Arthritis Index was measured for all patients. Results: The mean age of patients and controls were 60±3.5 and 54±2.6 years, respectively. Vitamin D levels of patients and controls were 13±3.3 and 32±2.5, respectively. More severe disease and diseases with prolonged duration were associated with a lower vitamin D level, and low vitamin D levels were associated with high VAS and WOMAC. Conclusion: Vitamin D deficiency was associated with the development and the severity of knee OA as well as with the disease duration. %U https://esmed.org/MRA/mra/article/view/3284 %J Medical Research Archives %0 Journal Article %R 10.18103/mra.v10i10.3284 %V 10 %N 10 %@ 2375-1924 %8 2022-10-31