@article{MRA, author = {Maria Mathias-Machado and Leandro Oliveira and Victor Fonseca de Jesus and Renata Peixoto}, title = { Molecular Features and Targeted Therapy in KRAS wild-type Pancreatic Cancer}, journal = {Medical Research Archives}, volume = {11}, number = {4}, year = {2023}, keywords = {}, abstract = {KRAS mutation is the major oncogenic event in approximately 90% of pancreatic ductal adenocarcinomas. The subset of patients with KRAS wild-type pancreatic ductal adenocarcinomas represent a distinct subgroup with a higher frequency of actionable genomic alterations. In this review article, we aim at exploring the more frequent molecular alterations found among KRAS wild-type pancreatic ductal adenocarcinomas, their prognostic implications, as well as the potential targetable therapeutic options beyond cytotoxic chemotherapy for this unique subset of patients.}, issn = {2375-1924}, doi = {10.18103/mra.v11i4.3764}, url = {https://esmed.org/MRA/mra/article/view/3764} }