@article{MRA, author = {Daliya Banerjee}, title = { Unraveling the Challenges in the Retinoid-related Orphan Receptor (ROR)-y(t) Therapeutic Landscape for Autoimmune Diseases}, journal = {Medical Research Archives}, volume = {12}, number = {4}, year = {2024}, keywords = {}, abstract = {RORyt/y driven type-17 “pro-inflammatory “gene expression profile has been implicated in the pathogenesis of several human immune-mediated diseases and remains a compelling target for therapeutic intervention. However, several challenges, from both drug discovery and biology standpoint, have made it intractable. While biologics targeting IL-23, IL-17, IL-17R, and other cytokines in the ROR pathway have demonstrated clinical efficacy in psoriasis, ankylosing spondylitis, etc., it has been challenging to extend the utility of these therapeutics beyond a handful of autoimmune diseases, especially in atopic or rheumatic diseases. This review summarizes the complexities in defining the pathogenicity of the human type-17 pathway and underscores the need for targeting a phenotypically heterogeneous and therapeutically relevant pathogenic cell subset marked by CD161.}, issn = {2375-1924}, doi = {10.18103/mra.v12i4.5306}, url = {https://esmed.org/MRA/mra/article/view/5306} }