@article{MRA, author = {Jelani, I and Abdullahi, HL and Alhassan, AJ and Dalhatu, MM and Dangambo, MA and Abacha, FZ and Haruna, S and Mahmud, RI and Yandutse, MI and Hamza, HD and Abdu, R and Musa, A. H}, title = { Molecular Characterization of Glucose-6-Phosphate Dehydrogenase deficient variants in Kano North-West Nigeria}, journal = {Medical Research Archives}, volume = {12}, number = {7}, year = {2024}, keywords = {}, abstract = {Studies from sub-Saharan Africa where malaria is endemic have observed high incidences of Glucose-6-phosphate dehydrogenase A- (G-6-PD A-) deficiency that sporadically leads to manifest haemolytic anaemia. The severity of this disease depends on the genetic variant involved, thus, pinpointing the type of G-6-PD variants will help in the management of G-6-PD deficiency. This is not exactly known among Hausa and Fulani ethnics in Northern Nigeria, hence the need for the study. Two ml of venous blood samples were collected from twenty (20) G-6-PD deficient individuals and dispensed into EDTA bottle to study the coding region of G-6-PD gene by using PCR-Sequencing techniques. Sequencing of the G-6-PD-deficient samples revealed two major polymorphic variants; A376G substitution (exon-5: Asn126Asp) and A376G/G202A substitution (exon-4: Val68Met) commonly observed among Hausa and Fulani ethnics. This is the first study of G-6-PD mutations in Kano, North-west Nigeria. The G-6-PD deficiency in Hausa and Fulani ethnics were associated with African variants (202A/376G G6PD A- allele) in exon 4 and no mutation was found within exon 6-7.}, issn = {2375-1924}, doi = {10.18103/mra.v12i7.5312}, url = {https://esmed.org/MRA/mra/article/view/5312} }