@article{MRA, author = {Priya Hays}, title = { CAR-NK therapy approaches for targeting the immunosuppressive tumor microenvironment in solid tumors}, journal = {Medical Research Archives}, volume = {12}, number = {10}, year = {2024}, keywords = {}, abstract = {Background: Adoptive cellular therapies have gained considerable ground while becoming an established form of therapy for hematologic malignancies, now a fifth pillar of treatment after chemotherapy, surgery, radiation and targeted therapies. The most prominent example is chimeric antigen T cell receptor therapies. These therapies have shown superior clinical efficacy in hematologic malignancies, but are less effective against solid tumors. This paper describes the combination of CAR T cells with the innate immune cells natural killer cells in solid tumors in the immunosuppressive tumor microenvironment. Results: CAR NK cells have been shown in a number of solid tumors in the context of the immunosuppressive tumor microenvironment to have clinical efficacy and exhibit superior safety profiles when compared with original CAR T cells. In preclinical models and ongoing clinical studies, anti-tumor activity has been shown in prostate cancer, hepatocellular carcinoma, glioblastoma and ovarian cancer that benefits from the inherent cytotoxicity of natural killer cells. Conclusion: Future studies should focus on using the advantages of CAR NK cells in clinical and translational settings.}, issn = {2375-1924}, doi = {10.18103/mra.v12i10.5750}, url = {https://esmed.org/MRA/mra/article/view/5750} }