@article{MRA, author = {Mustafa Zaman and Aseel Aljeshi and Kuragamage Kuraga and Saif Bunni and Tonmoy Sarker and Aiza Kashif and Jyothsnaa Sathish and Hussien Abouzeid and Hamza Alouf and Jessarij Chinthamraks and Adhved Krishnan and Shaan Patker and Simone Talreja and Datta Pentapati}, title = { Recreational Drugs Addiction, Withdrawal and its Impact on the body: A Literature Review}, journal = {Medical Research Archives}, volume = {13}, number = {3}, year = {2025}, keywords = {}, abstract = {The use of drugs for recreational purposes has changed dramatically, involving a variety of substances such as opioids, hallucinogens, and cannabinoids. Although these substances are often initially used for recreational purposes, their psychoactive properties can contribute to the development of addiction, withdrawal syndromes, and significant physical and mental health complications. The mechanisms behind addiction, symptoms of withdrawal, and the pathophysiology of frequently abused recreational drugs are all examined in this literature review. Dysregulation of the endocannabinoid system is associated with cannabinoid addiction, which can result in physical dependence, mental health issues, and cognitive impairment. A public health emergency has been exacerbated by opioid abuse, and withdrawal is marked by intense psychological and autonomic symptoms. Lysergic acid diethylamide (LSD), and Phencyclidine (PCP) are examples of hallucinogens that change neurotransmission and can cause neurotoxicity, long-lasting perceptual abnormalities, and mental illnesses. Long-term recovery is still difficult to achieve, despite the promise of pharmacological treatments like opioid agonists and cannabinoid receptor modulators. To lessen the worldwide burden of recreational drug abuse, comprehensive treatment approaches that include pharmacotherapy, psychosocial interventions, and harm reduction techniques are essential.}, issn = {2375-1924}, doi = {10.18103/mra.v13i3.6295}, url = {https://esmed.org/MRA/mra/article/view/6295} }