@article{MRA, author = {Murray P and Villalon R and Hartmann D}, title = { Decreased expression of matrix metalloproteinase-2 in bone marrow micro-metastasis after FOLFOX adjuvant chemotherapy for stage III colon cancer is association with an increased progression free survival and the elimination of circulating tumour cells}, journal = {Medical Research Archives}, volume = {13}, number = {3}, year = {2025}, keywords = {}, abstract = {Introduction: FOLFOX adjuvant chemotherapy is standard practice after curative surgery for stage III colon cancer. Even so there a significative number of patients who relapse. This study investigates the expression of metallo-proteinase (MMP-2) in bone marrow micro-metastasis and the progression free survival in these patients Methods: Bone marrow and blood samples were taken before and after chemotherapy to detect CEA expressing cancer cells and the expression of MMP-2 Results: Patients with bone marrow micro-metastasis expressing MMP-2 after chemotherapy had a lower progression free survival rate and a shorter time to relapse. Conclusions: The detection of MMP-2 positive micro-metastasis or CTCs may provide useful information of the prognosis of stage III colon cancer patients.}, issn = {2375-1924}, doi = {10.18103/mra.v13i3.6365}, url = {https://esmed.org/MRA/mra/article/view/6365} }