Abstract
Advancements in public health and medicine have increased global life expectancy, but most added years are spent in illness and disability, mainly due to brain diseases. A different approach is needed with a focus on the prevention of disease and the promotion of brain health and resilience to enhance each individual brain’s ability to cope with and minimize the functional consequences of any brain stressor, insult, injury, or disease. We propose a focus on brain health to address the threat of brain-related disability and promote human healthspan and well-being. We have outlined 10 key principles for optimizing brain health. Technology developments enable their implementation in clinical practice. Leveraging technology can help reach more people, provide personalized care, and improve access to essential brain health services.