Abstract
Background: B-type natriuretic peptide (BNP) and N-terminal pro-atrial natriuretic peptide (NT-proANP) plasma levels are linked to metabolic risk. Metabolic syndrome has been associated with lower levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) and insulin resistance.
Aim: This study aims to evaluate the association between NT-proBNP and insulin resistance, diabetes and cardiovascular (CV) risk factors.
Methods: A total of 183 subjects, aged 25-70 years were included in the study based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III) guidelines for metabolic syndrome. Anthropometric parameters, subclinical measurements and biochemical markers were measured. Gender-specific comparisons were conducted using unpaired t-tests. Correlation between NT-proBNP and insulin resistance in metabolic syndrome was assessed using regression analysis. A p-value of less than 0.05 was considered statistically significant.
Results: Of the 183 subjects, 58% were male and 42% were female. Key clinical parameters - such as blood pressure, body mass index (35.57±6.02 kg/m²) and waist circumference (95.50±9.75 cm) were measured. Other biochemical parameters, including elevated triglycerides, Low-Density Lipoprotein (LDL) cholesterol and blood sugar levels, as well as reduced insulin and NT-proBNP levels were observed. The study found an inverse relationship between NT-proBNP and insulin levels.
Conclusion: Females exhibited higher levels of NT-proBNP and insulin. This study identified an inverse relationship between NT-proBNP and insulin resistance.