Abstract
Polyoxometalates (PM) exhibit a wide range of biological activities, such as antimicrobial, antitumor, and antiviral properties against neurodegenerative diseases and have been investigated for applications in catalysis and energy accumulation. Some PMs are more active than existing medicines; however, they have not been applied. In order to utilize PM, which has been found to have a wide variety of biological activities, we have discovered the possibility of bringing it into the anti-aging field. Recently, the global average life expectancy has increased, and cancer and senescence reveal an integral relationship to this aspect. For example, in anti-aging research, eliminating senescent cells from the body can increase life expectancy. Cancerous cells are either arrested during cell division as they are perceived as senescent cells or directed toward cell death by apoptosis or ferroptosis. Cancer cells are also resistant to these processes. Such interactions between cancer cells and biological defense mechanisms can also be applied to normal cells, which may lead to anti-aging effects. This review focuses on the literature available on PM, identifies the effects that broadly encompass age-related diseases from conventional disease-by-disease correspondence, and describes its potential in novel aspects of anti-aging.