Abstract
Background: Aging is a multifactorial biological process that affects various tissues and structures at the cellular level. Advanced medical technologies that simultaneously target different skin layers may provide synergistic outcomes that surpass those of individual treatments.
Aims: To evaluate the safety and efficacy of a single-session multimodal treatment combining HIFES with Radiofrequency (RF), targeted ultrasound (TUS) with RF, and RF microneedling technologies for facial rejuvenation.
Methods: This prospective study enrolled 52 subjects who received the consecutive application of HIFES+RF, TUS+RF, and RF microneedling in one treatment session. Follow-up visits were conducted at 1 and 3 months post-treatment. Outcome measures included histological analysis of collagen, elastin, and hyaluronic acid (HA) density, 2D photographic evaluation using the Global Aesthetic Improvement Scale (GAIS), and 3D skin analysis with QuantifiCare software focusing on evenness, wrinkle depth, and pore size.
Results: At 3 months, collagen and elastin density increased by 39.53% and 130.04%, respectively, while HA density increased by 230.02%. GAIS scores indicated 100% of subjects showed overall facial improvement. Quantitative skin analysis revealed a 31.20% improvement in skin evenness, a 47.31% reduction in pores, and a 43.36% reduction in wrinkles. Additionally, 84.00% of subjects rated the treatment as comfortable, and 76.90% reported satisfaction with the results.
Conclusion: A single-session multimodal treatment combining HIFES+RF, TUS+RF, and RF microneedling is safe, well-tolerated, and effective in improving key markers of facial aging. The synergistic effects of this approach enhance dermal remodeling through multiple cellular pathways, supporting its clinical relevance in comprehensive facial rejuvenation.