Plasmacytoid Dendritic Cell Leukemia: Updated Review
Main Article Content
Jácome Sánchez Elisa Sánchez Elisa Carolina, Md Msc. Internist
http://orcid.org/0000-0002-3185-9112
Buestán Zumba María Eugenia, MD
http://orcid.org/0009-0001-2341-5263
Otáñez Molina Cristian Paul
http://orcid.org/0000-0003-2144-1836
Narváez Shadira, MD
http://orcid.org/0000-0003-2144-1836
Lara Abril Carolina, MD
http://orcid.org/0000-0002-0195-1583
Ramón Tigse Mónica Estefanía
http://orcid.org/0000-0002-3185-9112
Buestán Zumba María Eugenia, MD
http://orcid.org/0009-0001-2341-5263
Otáñez Molina Cristian Paul
http://orcid.org/0000-0003-2144-1836
Narváez Shadira, MD
http://orcid.org/0000-0003-2144-1836
Lara Abril Carolina, MD
http://orcid.org/0000-0002-0195-1583
Ramón Tigse Mónica Estefanía
Abstract
This review article compiles updated information on Plasmacytoid Dendritic Cell Leukemia, a type of uncommon or rare myeloid neoplasm, with typically cutaneous manifestations with or without extramedullary involvement and leukemic dissemination, which makes it difficult to differentiate from other neoplasms. This review aims to provide a brief update on key points such as its epidemiology, pathogenesis, diagnosis and treatment, in order to allow early recognition of the disease considering its rapid evolution and poor prognosis.
Keywords:
Dendritic, leukemia, plasmacytoid
Article Details
How to Cite
CAROLINA, Jácome Sánchez Elisa Sánchez Elisa et al.
Plasmacytoid Dendritic Cell Leukemia: Updated Review.
Medical Research Archives, [S.l.], v. 12, n. 5, may 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/5291>. Date accessed: 04 dec. 2024.
doi: https://doi.org/10.18103/mra.v12i5.5291.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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2. Lee YJ, Kim Y, Park SH, Jo JC. Plasmacytoid dendritic cell neoplasms. Blood Res. 2023;58:S90–5
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5. Laribi K, Denizon N, Besançon A, Farhi J, Lemaire P, Sandrini J, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm: From Origin of the Cell to Targeted Therapies. Biol Blood Marrow Transplant [Internet]. 2016;22(8):1357–67. Available from: http://dx.doi.org/10.1016/j.bbmt.2016.03.022
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8. Cazzato G, Capuzzolo M, Bellitti E, De Biasi G, et al. Blastic Plasmocytoid Dendritic Cell Neoplasm (BPDCN): Clinical Features and Histopathology with a Therapeutic Overview. Hematol. Rep. 2023, 15, 696–706. https://doi.org/10.3390/hematolrep15040070
9. Ohgami R, Aung P, Gru A, Hussaini M, Singh K, et al. An Analysis of the Pathologic Features of Blastic Plasmacytoid Dendritic Cell Neoplasm Based on a Comprehensive Literature Database of Cases. Arch. Pathol. Lab. Med. 2023, 147, 837–846
10. Cuglievan B, Connors J, He J, Khazal S, Yedururi S, Dai J, et al. Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies. Leukemia. 2023, 37(9):1767-1778. doi: 10.1038/s41375-023-01968-z. Epub 2023 Jul 14.
11. Deconinck E, Petrella T, Garnache Fr. Blastic plasmacytoid dendritic cell neoplasm (BPDCN): clinic and diagnosis. Hematol Oncol Clin North Am. 2020;34(3):491-500. doi: 10.1016/j.hoc.2020.01.010.
12. Garnache F, Feuillard J, Ferrand C, Biichle S, Trimoreau F, et al. Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia. Br J Haematol. 2009;145(5):624-36.
13. Grushchak S, Joy C, Gray A, Opel D, Speiser J, et al. Novel treatment of blastic plasmacytoid dendritic cell neoplasm: A case report. Medicine (Baltimore). 2017,96(51):e9452. http://dx.doi.org/10.1097/MD.0000000000009452
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16. Pemmaraju N, Deconinck E, Mehta P, Walker I, Herling M, et al. Recent Advances in the Biology and CD123-Directed Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm. Clin Lymphoma Myeloma Leuk. 2024;24(4):e130-e137.
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18. Shumilov E, Ghandili P, Künstner S, Weidemann A, Banz S, et al. Diagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations. Annals of Hematology. 2024, 1-13. 10.1007/s00277-023-05587-7.
19. Tsagarakis N, Paterakis G. Dendritic Cell Leukemia: a Review. Curr Oncol Rep. 2020, 22(6):55. doi: 10.1007/s11912-020-00921-y.
2. Lee YJ, Kim Y, Park SH, Jo JC. Plasmacytoid dendritic cell neoplasms. Blood Res. 2023;58:S90–5
3. Annapurna Singh. Daulath Singh. Blastic Plasmacytoid Dendritic Cell Neoplasm. Treasure Island (FL): StatPearls Publishing; 2024. [Internet].
4. Mehra S, Taylor J. Blastic Plasmacytoid Dendritic Cell Neoplasm: A Comprehensive Review of the Disease, Central Nervous System Presentations, and Treatment Strategies. Cells. 2024;13(3)
5. Laribi K, Denizon N, Besançon A, Farhi J, Lemaire P, Sandrini J, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm: From Origin of the Cell to Targeted Therapies. Biol Blood Marrow Transplant [Internet]. 2016;22(8):1357–67. Available from: http://dx.doi.org/10.1016/j.bbmt.2016.03.022
6. Venugopal S, Zhou S, El Jamal S, Lane A, Mascarenhas J. Blastic Plasmacytoid Dendritic Cell Neoplasm–Current Insights. Clin Lymphoma, Myeloma Leuk [Internet]. 2019;19(9):545–54. Available from: https://doi.org/10.1016/j.clml.2019.06.002
7. Cheng W, Yu T tian, Tang A ping, He Young K, Yu L. Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches. Curr Med Sci. 2021;41(3):405–19
8. Cazzato G, Capuzzolo M, Bellitti E, De Biasi G, et al. Blastic Plasmocytoid Dendritic Cell Neoplasm (BPDCN): Clinical Features and Histopathology with a Therapeutic Overview. Hematol. Rep. 2023, 15, 696–706. https://doi.org/10.3390/hematolrep15040070
9. Ohgami R, Aung P, Gru A, Hussaini M, Singh K, et al. An Analysis of the Pathologic Features of Blastic Plasmacytoid Dendritic Cell Neoplasm Based on a Comprehensive Literature Database of Cases. Arch. Pathol. Lab. Med. 2023, 147, 837–846
10. Cuglievan B, Connors J, He J, Khazal S, Yedururi S, Dai J, et al. Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies. Leukemia. 2023, 37(9):1767-1778. doi: 10.1038/s41375-023-01968-z. Epub 2023 Jul 14.
11. Deconinck E, Petrella T, Garnache Fr. Blastic plasmacytoid dendritic cell neoplasm (BPDCN): clinic and diagnosis. Hematol Oncol Clin North Am. 2020;34(3):491-500. doi: 10.1016/j.hoc.2020.01.010.
12. Garnache F, Feuillard J, Ferrand C, Biichle S, Trimoreau F, et al. Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia. Br J Haematol. 2009;145(5):624-36.
13. Grushchak S, Joy C, Gray A, Opel D, Speiser J, et al. Novel treatment of blastic plasmacytoid dendritic cell neoplasm: A case report. Medicine (Baltimore). 2017,96(51):e9452. http://dx.doi.org/10.1097/MD.0000000000009452
14. Pagano L, Valentini CG, Pulsoni A, Fisogni S, Carluccio P, et al; GIMEMA-ALWP (Gruppo Italiano Malattie EMatologiche dell'Adulto, Acute Leukemia Working Party). Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. Haematologica. 2013; 98(2):239-46. doi: 10.3324/haematol.2012.072645. Epub 2012 Oct 12. PMID: 23065521; PMCID: PMC3561431
15. Wang Y, Xiao L, Yin L, Zhou L, Deng Y, Deng H. Diagnosis, treatment, and genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A review. Medicine (Baltimore). 2023;102(7):e32904. doi: 10.1097/MD.0000000000032904
16. Pemmaraju N, Deconinck E, Mehta P, Walker I, Herling M, et al. Recent Advances in the Biology and CD123-Directed Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm. Clin Lymphoma Myeloma Leuk. 2024;24(4):e130-e137.
17. Hammond D, Pemmaraju N. Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm. Hematol Oncol Clin N Am 34 (2020) 565–574 https://doi.org/10.116/j.hoc.2020.01.005
18. Shumilov E, Ghandili P, Künstner S, Weidemann A, Banz S, et al. Diagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations. Annals of Hematology. 2024, 1-13. 10.1007/s00277-023-05587-7.
19. Tsagarakis N, Paterakis G. Dendritic Cell Leukemia: a Review. Curr Oncol Rep. 2020, 22(6):55. doi: 10.1007/s11912-020-00921-y.