Abstract
Most of advantage stages of HCC is going into cachexia with asictes which is lacking an effective treatment. Ferroptosis-Enhanced Immunotherapy is used for treating ascites of HCC by an chitosan hydrochloride and oxidized dextran (CH-OD) designed to load sulfasalazine (SSZ). Since iron sucrose (IS) commonly used for treating iron deficiency by IV injection and iron is a critical component of many cellular functions. However, excess iron can be highly toxic, resulting in oxidative DNA damage to induce cancer cell death which is called a ferroptosis. Our current study has indicated that the interaction between mesothelial cells, MPs, neutrophils, TandNK and B cells are induced by IS local fusion treatment ascites of HCC, which promotes the expression of a large number of genes and leads to upregulation of immune response and feroptosis. Our evidence of study has approved local delivery IS can be used as ferroptosis inducer for ferronan immune adjuvant in treatment of cancer ascites of HCC.