Ferroptosis Induced Following Iron Sucrose Injection into Ascites of Hepatocellular Carcinoma

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Published Apr 30, 2025
DOI: https://doi.org/10.18103/mra.v13i4.6472

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Main Article Content

Baofa Yu, MD
TaiMei Baofa Cancer hospital, Dong ping, Shandong, China, 271500; Jinan Baofa Cancer Hospital, Jinan, Shandong, China, 250000; Beijing Baofa Cancer Hospital, Beijing, China, 100010; South China Hospital of Shenzhen University, Shenzhen, China, 518055; Immune Oncology Systems, Inc, San Diego, CA, USA, 92102
Hongxi Zhang
TaiMei Baofa Cancer hospital, Dong ping, Shandong, China, 271500
Peng Jing, MD
TaiMei Baofa Cancer hospital, Dong ping, Shandong, China, 271500
Feng Gao, MD
TaiMei Baofa Cancer hospital, Dong ping, Shandong, China, 271500
Guoqin Zheng, Ms
TaiMei Baofa Cancer hospital, Dong ping, Shandong, China, 271500

Abstract

Most of advantage stages of HCC is going into cachexia with asictes which is lacking an effective treatment. Ferroptosis-Enhanced Immunotherapy is used for treating ascites of HCC by an chitosan hydrochloride and oxidized dextran (CH-OD) designed to load sulfasalazine (SSZ). Since iron sucrose (IS) commonly used for treating iron deficiency by IV injection and iron is a critical component of many cellular functions. However, excess iron can be highly toxic, resulting in oxidative DNA damage to induce cancer cell death which is called a ferroptosis. Our current study has indicated that the interaction between mesothelial cells, MPs, neutrophils, TandNK and B cells are induced by IS local fusion treatment ascites of HCC, which promotes the expression of a large number of genes and leads to upregulation of immune response and feroptosis. Our evidence of study has approved local delivery IS can be used as ferroptosis inducer for ferronan immune adjuvant in treatment of cancer ascites of HCC.

Keywords: iron sucrose, ferroptosis, immunotherapy with iron sucrose, local immune inducer, local immune booster

Article Details

How to Cite
YU, Baofa et al. Ferroptosis Induced Following Iron Sucrose Injection into Ascites of Hepatocellular Carcinoma. Medical Research Archives, [S.l.], v. 13, n. 4, apr. 2025. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/6472>. Date accessed: 15 may 2025. doi: https://doi.org/10.18103/mra.v13i4.6472.
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Issue
Vol 13 No 4 (2025): Vol.13, Issue 4, April 2025
Section
Research Articles

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