Abstract
The erosion of U.S. leadership in global health—marked most visibly by uncertainty around its flagship initiative (PEPFAR)—has created a leadership vacuum with far-reaching implications. This editorial argues that Europe, through its support of multilateral institutions, strategic financing tools, and growing commitment to equitable health systems, is uniquely positioned to make greater contributions. It also highlights the leadership of African governments and regional actors, and the growing regional vision of health and renewed partnership. It further emphasizes the importance of sustainable financing models and the opportunity for Europe to grow its role as an innovator and modern partner in global health. Drawing from recent actions by the EU, Germany, France, and the UK, we call for a redefined global health agenda grounded in partnership, solidarity, and long-term resilience.