Eosinophilic Esophagitis: Review and Update
Main Article Content
Abstract
Background: Eosinophilic esophagitis is a chronic, antigen-mediated disease of the esophagus that causes dysphagia and swallowing in adults, with nonspecific symptoms of esophageal dysfunction and/or alterations in swallowing in children, and sometimes with esophageal stenosis in both unless treatment is prescribed. Characteristics. EoE courses with symptoms of esophageal dysfunction, especially in adults, such as dysphagia and choking. In children, esophageal symptoms are more nonspecific and also involve alterations in swallowing. In addition, they are necessary for the diagnosis of ≥15 eosinophils per field of large increase in at least one biopsy of the esophagus, and other causes of esophageal eosinophilia must be ruled out. Treatment can be with food elimination diets (elementary, empirical, or according to allergy tests), or pharmacological (proton pump inhibitor drugs, deglutidated topical corticoids, and dupilumab). When there is esophageal stenosis, the treatment would be esophageal dilatation.
Objetives: This review offers a general and practical overview of the recent literature on EoE (epidemiology, etiopathogeny, pathophysiology, diagnosis, prognosis, and treatment).
Methods: The team performed a bibliographic search on PubMed between February -2019 tJune-2025. Keywords used in the search: eosinophilic esophagitis, epidemiology, etiopathogeny, pathophysiology, symptoms, diagnosis, natural history, prognosis, therapy/treatment. In total we use reviewed 100 articles on EoE for the preparation of this review and update.
Results: This review provides an updated and comprehensive overview of multiple aspects of eosinophilic esophagitis, as outlined in the study objectives. Each characteristic was analyzed in light of the most recent evidence to reflect current understanding and clinical practice.
Conclusions: Primary eosinophilic gastrointestinal disease affecting the esophagus exclusively, characterized by chronic, antigen-triggered inflammation. Symptoms vary depending on whether they are children or adults. Diagnosis is made by esophageal symptoms and/or alterations in swallowing and ≥15 eosinophils /HPF in at least one of the esophageal biopsies, after ruling out other causes of esophageal eosinophilia. Complications can arise if patients are undiagnosed and untreated, both in the short and long term. EoE is frequently associated with atopic comorbidities. They also tend to have digestive comorbidities, although to a lesser extent. Autoimmune and other connective tissue diseases are not relevant. Treatment may be with food elimination diets or with drugs, and to assess the response to the same is the precise disappearance of the symptoms and eosinophils of the esophageal mucosa.
Keywords:
Eosinophilic esophagitis, epidemiology, etiopathogeny, pathophysiology, symptoms, diagnosis, treatment
Article Details
How to Cite
GÓMEZ, Alejandro Raúl Gratacós et al.
Eosinophilic Esophagitis: Review and Update.
Medical Research Archives, [S.l.], v. 13, n. 8, aug. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6864>. Date accessed: 05 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i8.6864.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1.Erdle SC, Carr S, Chan ES, Robertson K, Watson W. Eosinophilic esophagitis. Allergy Asthma Clin Immunol. 2024 Dec 19;20(Suppl 3):72. Doi: 10.1186/s13223-024-00929-0.
2. Horwitz A, Yunus S. Eosinophilic Esophagitis: A Review for the Primary Care Practitioner. Med Clin North Am. 2024 Jul;108(4):733-745. Doi: 10.1016/j.mcna. 2023.08.010.
3. Dellon ES, Muir AB, Katzka DA, Shah SC, Sauer BG, Aceves SS, Furuta GT, Gonsalves N, Hirano I. ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. Am J Gastroenterol. 2025 Jan 1;120(1):31-59. Doi: 10.14309/ajg.000000000 0003194. Epub 2025 Jan 2.
4. Allin KH, Poulsen G, Melgaard D, Frandsen LT, Jess T, Krarup AL. Eosinophilic oesophagitis in Denmark: Population-based incidence and prevalence in a nationwide study from 2008 to 2018. United European Gastroenterol J. 2022 Sep;10(7):640-650. Doi: 10.1002/ueg2.12273. Epub 2022 Sep 15. PMID: 36106558;
5. Garber JJ, Lochhead PJ, Uchida AM, Roelstraete B, Bergman D, Clements MS, Ludvigsson JF. Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study. Esophagus. 2022 oct;19(4):535-541. Doi: 10.1007/s10388-022-00926-5. Epub 2022 Jun 2
6. Sawada A, Imai T, Ihara Y, Tanaka F, Hirano I, Fujiwara Y. Epidemiology and Risk Factors of Eosinophilic Esophagitis in Japan: A Population-Based Study. Clin Gastroenterol Hepatol. 2024 oct;22(10):2023-2032.e6. Doi: 10.1016/j.cgh.2024.04.035.
7. Roussel JM, Pandit S. Eosinophilic Esophagitis. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29083829
8. Gautam Y, Caldwell J, Kottyan L, Chehade M, Dellon ES, Rothenberg ME, Mersha TB; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) investigators. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. J Allergy Clin Immunol. 2023 May;151(5):1337-1350. Doi: 10.1016/j.jaci.2022. 09.040.
9. Muir A, Falk GW. Eosinophilic Esophagitis: A Review. JAMA. 2021 oct 5;326(13):1310-1318. Doi: 10.1001/jama.2021.14920
10. Thel HL, Anderson C, Xue AZ, Jensen ET, Dellon ES. Prevalence and Costs of Eosinophilic Esophagitis in the United States. Clin Gastroenterol Hepatol. 2025 feb;23(2):272-280.e8. Doi: 10.1016/j.cgh.2024.09. 03.
11. Gratacós Gómez AR, Gómez Torrijos E. Eosinophilic Esophagitis due to Aeroallergens: A Systematic Review and Update. J Investig Allergol Clin Immunol. 2022 Dec 15;32(6):438-450. Doi: 10.18176/jiaci.0853.
12. Lehman HK, Lam W. Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2021 Nov;41(4):587-598. Doi: 10.1016/j.iac.2021.07.011.
13. Patel RV, Hirano I, Gonsalves N. Eosinophilic Esophagitis: Etiology and Therapy. Annu Rev Med. 2021 Jan 27; 72:183-197. Doi: 10.1146/annurev-med-052819-023848.
14. Kennedy KV, Muir AB, Ruffner MA. Pathophysiology of Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2024 May;44(2):119-128. Doi: 10.1016/j.iac.2023.12.001.
15.Ji R, Cui X, Zhi Y. Eosinophilic esophagitis and allergic susceptibility: A systematic review and meta-analysis. World Allergy Organ J. 2025 Apr 25;18(5):101054. Doi: 10.1016/j.waojou.2025.101054
16. Alkhowaiter S. Eosinophilic esophagitis. Saudi Med J. 2023 Jul;44(7):640-646. Doi: 10.15537/smj.2023. 44.7.20220812.
17. Arias Á, Lucendo AJ. Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice. Expert Rev Gastroenterol Hepatol. 2019 Feb;13(2):99-117. Doi: 10.1080/17474124.2019.1546120
18. Fernandez-Becker NQ, Raja S, Scarpignato C, Lynch KL, Ahuja NK, Horsley-Silva JL. Eosinophilic esophagitis: updates on key unanswered questions. Ann N Y Acad Sci. 2020 Dec;1481(1):30-42. Doi: 10.1111/nyas. 14421
19. Lim AH, Wong S, Nguyen NQ. Eosinophilic Esophagitis and IgG4: Is There a Relationship? Dig Dis Sci. 2021 Dec;66(12):4099-4108. Doi: 10.1007/s10620-020-06788-0.
20. McGowan EC, Singh R, Katzka DA. Barrier Dysfunction in Eosinophilic Esophagitis. Curr Gastroenterol Rep. 2023 Dec;25(12):380-389. Doi: 10.1007/s11894-023-00904-6. Epub 2023 Nov 11
21. Underwood B, Troutman TD, Schwartz JT. Breaking down the complex pathophysiology of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2023 Jan;130(1):28-39. Doi: 10.1016/j.anai.2022.10.026.
22. Sciumè GD, Visaggi P, Sostilio A, et al. Esofagitis eosinofílica: nuevos conceptos sobre patogénesis y manifestaciones clínicas. Minerva Gastroenterology. Marzo de 2022;68(1):23-39. DOI: 10.23736/s2724-5985.20.02807-x.
23. de Bortoli N, Visaggi P, Penagini R, Annibale B, Baiano Svizzero F, Barbara G, Bartolo O, Battaglia E, Di Sabatino A, De Angelis P, Docimo L, Frazzoni M, Furnari M, Iori A, Iovino P, Lenti MV, Marabotto E, Marasco G, Mauro A, Oliva S, Pellegatta G, Pesce M, Privitera AC, Puxeddu I, Racca F, Ribolsi M, Ridolo E, Russo S, Sarnelli G, Tolone S, Zentilin P, Zingone F, Barberio B, Ghisa M, Savarino EV. The 1st EoETALY Consensus on the Diagnosis and Management of Eosinophilic Esophagitis - Definition, Clinical Presentation and Diagnosis. Dig Liver Dis. 2024 jun;56(6):951-963. Doi: 10.1016/j.dld.2024.02.005.
24. Visaggi P, Savarino E, Sciume G, Chio TD, Bronzini F, Tolone S, Frazzoni M, Pugno C, Ghisa M, Bertani L, Bellini M, Savarino V, Peroni D, Marchi S, de Bortoli N. Eosinophilic esophagitis: clinical, endoscopic, histologic and therapeutic differences and similarities between children and adults. Therap Adv Gastroenterol. 2021 Jan 31; 14:1756284820980860. Doi: 10.1177/ 1756284820980860.
25. Xu X, Kwiatek J, Siddall J, Genofre E, Stirnadel-Farrant H, Katial R. Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-world clinical practice. BMC Gastroenterol. 2024 Aug 3;24(1):246. Doi: 10.1186/s12876-024-03334-4
26. Taft TH, Carlson DA, Simons M, Zavala S, Hirano I, Gonsalves N, Pandolfino JE. Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis. Gastroenterology. 2021 Oct;161(4):1133-1144. Doi: 10.1053/j.gastro.2021.06.023. Epub 2021 Jun 19. PMID: 34153298.
27. Chang JW, Chen VL, Rubenstein JH, Dellon ES, Wallner LP, De Vries R. What patients with eosinophilic esophagitis may not share with their providers: a qualitative assessment of online health communities. Dis Esophagus. 2022 Jun 15;35(6):doab073. Doi: 10.1093/dote/doab073
28. Gold BD, Goodwin B, Davis K, Sweeney C, Reynolds M, Jiang J, Fan T, Boules M, Chen ST, Katzka DA. Health-Related Quality of Life and Perceived Stigma in Eosinophilic Esophagitis: A Real-World, US, Web-Based Survey. Gastro Hep Adv. 2024 Jul 30;3(8):1087-1097. Doi: 10.1016/j.gastha.2024.07.015
29. Rooij WE, Evertsz FB, Lei A, Bredenoord AJ. General Well-being and Coping Strategies in Adult Eosinophilic Esophagitis Patients. J Neurogastroenterol Motil. 2022 Jul 30;28(3):390-400. Doi: 10.5056/jnm21143.
30. Schreiner P, Safroneeva E, Rossel JB, Limacher A, Saner C, Greuter T, Schoepfer A, Straumann A, Biedermann L. Sex Impacts Disease Activity But Not Symptoms or Quality of Life in Adults With Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1729-1738.e1. Doi: 10.1016/j.cgh.2021.11.009.
31. Meyer R, Cianferoni A, Vazquez-Ortiz M. An update on the diagnosis and management of non-IgE-mediated food allergies in children. Pediatr Allergy Immunol. 2025 Mar;36(3):e70060. Doi: 10.1111/pai.70060. PMID: 40110885.
32. Hoerning A, Steiss JO, Madisch A, de Laffolie J. Eosinophilic Esophagitis: Prevalence, Diagnosis, and Treatment in Childhood and Adulthood. Dtsch Arztebl Int. 2025 Apr 4;(Forthcoming): arztebl.m2025.0042. Doi: 10.3238/arztebl.m2025.0042
33. O'Shea D, Quinn E, Middlesworth W, Khlevner J. Diagnosis and Management of Long-term Gastrointestinal Complications in Pediatric Esophageal Atresia/Tracheoesophageal Fistula. Curr Gastroenterol Rep. 2025 Feb 25;27(1):16. Doi: 10.1007/s11894-025-00968-6.
34. Farah A, Assaf T, Hindy J, Abboud W, Mahamid M, Savarino EV, Mari A. The Dynamic Evolution of Eosinophilic Esophagitis. Diagnostics (Basel). 2025 Jan 21;15(3):240. Doi: 10.3390/diagnostics15030240.
35. Barchi A., Vespa E., Passaretti S., Dell’anna G., Fasulo E., Yacoub M.-R., Albarello L., Sinagra E., Massimino L., Ungaro F., et al. The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders-A Comprehensive Review. Diagnostics. 2024; 14:858. Doi: 10.3390/diagnostics14080858
36. de Bortoli N., Visaggi P., Penagini R., Annibale B., Svizzero F.B., Barbara G., Bartolo O., Battaglia E., Di Sabatino A., De Angelis P., et al. The 1st EoETALY Consensus on the Diagnosis and Management of Eosinophilic Esophagitis—Current Treatment and Monitoring. Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver. 2024; 56:1173–1184. Doi: 10.1016/j.dld.2024.02.020.
37. Gupta M, Grinman M. Diagnosis and management of eosinophilic esophagitis. CMAJ. 2024 feb 4;196(4): E121-E128. Doi: 10.1503/cmaj.230378
38.Papadopoulou A., Amil-Dias J., Auth M.K.H., Chehade M., Collins M.H., Gupta S.K., et al. Joint ESPGHAN/NASPGHAN guidelines on childhood eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2024; 78:122–152. Doi: 10.1097/MPG.0000000000003877.
39. Gonzalez-Uribe V, Hernandez-Zarate LA, Pozo Beltran CF, Alcocer-Arreguin CR, de Baro Alvarez P, Coello-Niembro N, Jimenez-Feria P, Mojica Gonzalez ZS, Gomez-Nuñez CA, Martinez-Tenopala R, Basile-Alvarez MR, Velasco-Benhumea B, Fernandez-Soto R, García-Fajardo DE, Perez-Avilés H, Pinto-Solis C, Rios-Villalobos LA, Ureña-Ortiz R, Lezama-Vazquez L, Acosta-Rodriguez-Bueno P, Del Rio-Navarro BE. Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico. J Allergy Clin Immunol Glob. 2024 Dec 18;4(1):100392. Doi: 10.1016/j.jacig.2024.100392
40. Almazan E, Liang TZ, Hohl B, Hoskins BJ, Birkness-Gartman JE, Ng K. EndoFLIP distensibility index correlates with histologic findings in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2025 May;80(5):824-831. Doi: 10.1002/jpn3.70013.
41. Lin B, Rabinowitz S, Haseeb MA, Gupta R. Usefulness of the eosinophilic esophagitis histologic scoring system in distinguishing active eosinophilic esophagitis from remission and gastroesophageal reflux disease. Gastroenterol Res. 2021; 14(4): 220-226.
42. Hoffmann NV, Keeley K, Wechsler JB. Esophageal distensibility defines fibrostenotic severity in pediatric eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2023; 21: 1188-1197.e4. Doi:10.1016/j.cgh.2022.08.044
43. Sykes C.M., Fairlamb G.M., Fox M.M., Sweis R. Assessment of Esophageal Motility in Patients With Eosinophilic Esophagitis: A Scoping Review. J. Clin. Gastroenterol. 2023;57:10–30. Doi: 10.1097/MCG.0000000000001792.
44. Nguyen N, Lavery WJ, Capocelli KE, Smith C, DeBoer EM, Deterding R, Prager JD, Leinwand K, Kobak GE, Kramer RE, Menard-Katcher C, Furuta GT, Atkins D, Fleischer D, Greenhawt M, Friedlander JA. Transnasal Endoscopy in Unsedated Children With Eosinophilic Esophagitis Using Virtual Reality Video Goggles. Clin Gastroenterol Hepatol. 2019 nov;17(12):2455-2462. Doi: 10.1016/j.cgh.2019.01.023. Epub 2019 Jan 29.
45. Visaggi P, Solinas I, Baiano Svizzero F, Bottari A, Barberio B, Lorenzon G, Ghisa M, Maniero D, Marabotto E, Bellini M, de Bortoli N, Savarino EV. Non-Invasive and Minimally Invasive Biomarkers for the Management of Eosinophilic Esophagitis beyond Peak Eosinophil Counts: Filling the Gap in Clinical Practice. Diagnostics (Basel). 2023 Aug 30;13(17):2806. Doi: 10.3390/diagnostics13172806.
46. Sebastian-Delacruz M, Garcia-Etxebarria K, Bilbao JR, Lucendo AJ, Bujanda L, Castellanos-Rubio A. A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels. Clin Gastroenterol Hepatol. 2024 Mar;22(3):656-658.e3. Doi: 10.1016/j.cgh.2023.07.023.
47. Fass OZ, Clarke JO. Reflux, eosinophilic esophagitis, and celiac disease - the blurred lines. Curr Opin Otolaryngol Head Neck Surg. 2024 Dec 1;32(6):367-373. Doi: 10.1097/MOO.0000000000000989.
48. Hussein M, Mitchison M, Sweis R. Lymphocytic oesophagitis: diagnosis and management. Clin Med (Lond). 2023 nov;23(6):540-544. Doi: 10.7861/clinmed.2023-0440.
49. Resende F, Ferrão A, Melo R, Barbosa E Sr, Barbosa A. A New Differential Diagnosis of Dysphagia: A Case Report of Lymphocytic Esophagitis. Cureus. 2021 Jan 30;13(1):e13010. Doi: 10.7759/cureus.13010.
50. Avila M, Ambelil M, Tong Y, Khurana S, Abraham F, Ertan A, Thosani NC, DuPont AW, Cash BD, Younes M. Lymphocytic Esophagitis Is Not Similar to Eosinophilic Esophagitis Except for Seasonal Variation. Ann Clin Lab Sci. 2021 May;51(3):347-351.
51. Jradi A, Khoury KM, Karam K, El Hajj DII, Fiani E. Lymphocytic Esophagitis: Navigating an Uncharted Territory. J Investig Med High Impact Case Rep. 2025 Jan-Dec; 13:23247096251313734. Doi: 10.1177/23247096251313734.
52. Khan S, Guo X, Liu T, Iqbal M, Jiang K, Zhu L, Chen X, Wang BM. An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications. Digestion. 2021;102(3):342-356. Doi: 10.1159/000508191.
53. Gratacós Gómez AR, Meneses Sotomayor JV, Joyanes Romo JB, Palacios Cañas A, Gonzalez Lopez L, Gomez Torrijos E. Symptoms and complications that require urgent treatment and upper digestive comorbidities in eosinophilic esophagitis. Dig Liver Dis. 2022 Jun;54(6):842-844. Doi: 10.1016/j.dld.2022.03.015. Epub 2022 Apr 11.
54. Khan S, Guo X, Liu T, Iqbal M, Jiang K, Zhu L, Chen X, Wang BM. An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications. Digestion. 2021;102(3):342-356. Doi: 10.1159/000508191.
55. Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology. 2022 Jul;163(1):59-76. Doi: 10.1053/j.gastro.2022.03.025.
56. Issa D, Alwatari Y, Smallfield GB, Shah RD. Spontaneous transmural perforation in eosinophilic esophagitis: RARE case presentation and role of esophageal stenting. J Surg Case Rep. 2019 Jun 14;2019(6):rjz190. Doi: 10.1093/jscr/rjz190
57. Fianchi F, De Matteis G, Cianci R, Pizzoferrato M, Cardone S, Nicolazzi MA, Fuorlo M, Congedo MT, Arena V, Riccioni ME, Barbaro B, Gambassi G. Acute intramucosal dissection in eosinophilic esophagitis. Clin J Gastroenterol. 2019 Dec;12(6):525-529. Doi: 10.1007/s12328-019-00990.
58. Bose, P., Kumar, S., Nebesio, T. D., Li, C., Hon, E. C., Atkins, D., Furuta G. T, Gupta, S. K. Adrenal insufficiency in children with eosinophilic esophagitis treated with topical corticosteroids. Journal of Pediatric Gastroenterology and Nutrition. 2020. 70(3), 324-329.
59. Redd WD, Ocampo AA, Xue Z, Chang NC, Thakkar KP, Reddy SB, Greenberg SB, Lee CJ, Ketchem CJ, Eluri S, Reed CC, Dellon ES. Eosinophilic esophagitis patients with multiple atopic conditions: Clinical characteristics and treatment response topical steroids. Ann Allergy Asthma Immunol. 2023 Jul;131(1):109-115.e2. Doi: 10.1016/j.anai.2023.04.026.
60. Capucilli P, Hill DA. Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications. Clin Rev Allergy Immunol. 2019 Aug;57(1):111-127. Doi: 10.1007/s12016-019-08733-0.
61. Jaros J, Ahuja K, Lio P. Exploring the Link Between Atopic Dermatitis and Eosinophilic Esophagitis. J Clin Aesthet Dermatol. 2025 Mar;18(3):15-20. PMID: 40135176.
62. Burk CM, Shreffler WG. Triggers for eosinophilic esophagitis (EoE): The intersection of food allergy and EoE. J Allergy Clin Immunol. 2024 Jun;153(6):1500-1509. Doi: 10.1016/j.jaci.2024.04.010.
63. Gabryszewski SJ, Dudley J, Shu D, Faerber JA, Grundmeier RW, Fiks AG, et al. Patrones en el desarrollo de la alergia pediátrica. Pediatría 2023;152.
64. Cafone J, Capucilli P, Hill DA, Spergel JM. Eosinophilic esophagitis during sublingual and oral allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):350-357. Doi: 10.1097/ACI.0000000000000537.
65. Jin H, Trogen B, Nowak-Wegrzyn A. Eosinophilic esophagitis as a complication of food oral immunotherapy. Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):616-623. Doi: 10.1097/ACI.0000000000000688.
66. Gratacós Gómez AR, Meneses Sotomayor JV, Joyanes Romo JB, Palacios Cañas A, Gonzalez Lopez L, Gomez Torrijos E. Symptoms and complications that require urgent treatment and upper digestive comorbidities in eosinophilic esophagitis. Dig Liver Dis. 2022 Jun;54(6):842-844. Doi: 10.1016/j.dld.2022.03.015.
67. Wojas O, Krzych-Fałta E, Żybul P, Żalikowska-Gardocka M, Ilczuk T, Furmańczyk K, Samoliński B, Przybyłkowski A. The Overlap of Allergic Disorders and Upper Gastrointestinal Symptoms: Beyond Eosinophilic Esophagitis. Nutrients. 2025 Apr 16;17(8):1355. Doi: 10.3390/nu17081355..
68. Ketchem CJ, Starling AS. Insights into the natural history and disease course of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2025 Mar 29:S1081-1206(25)00154-1. Doi: 10.1016/j.anai.2025.03.019.
69. Molina-Infante J, Rodríguez-Lago I. Modifying the natural history of gastrointestinal diseases in Europe as a result of early diagnosis: From eosinophilic esophagitis to inflammatory bowel disease. United European Gastroenterol J. 2022 Sep;10(7):612-613. Doi: 10.1002/ueg2.12256. Epub 2022 May 25.
70. Strauss Starling A, Ren Y, Li H, Spergel JM, Muir AB, Lynch KL, Liacouras CA, Falk GW. Reducing Eosinophil Counts in Eosinophilic Esophagitis in Children Is Associated With Reduction in Later Stricture Development. Am J Gastroenterol. 2024 Oct 1;119(10):2002-2009. Doi: 10.14309/ajg.0000000000002830
71. Wong S, Ellison S, Haj Ali S, Hawkes J, Collinson J, O'Neill T, Ruszkiewicz A, Moore D, Holloway RH, Nguyen NQ. Characteristics and progression of childhood-onset and adult-onset eosinophilic esophagitis. J Gastroenterol Hepatol. 2022 Jan;37(1):69-74. Doi: 10.1111/jgh.15660.
72. McGowan EC, Wright BL, Ruffner MA, Pesek RD, Rothenberg ME, Spergel JM, Dellon ES, Aceves SS. Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines. J Allergy Clin Immunol. 2025 May 6:S0091-6749(25)00510-X. Doi: 10.1016/j.jaci.2025.04.026.
73. Abe Y, Kikuchi R, Sasaki Y, Mizumoto N, Yagi M, Onozato Y, Watabe T, Goto H, Miura T, Sato R, Ito M, Tsuchiya H, Ueno Y. Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis. Endosc Int Open. 2024 Apr 15;12(4):E545-E553. Doi: 10.1055/a-2280-8277.
74. Suzuki Y, Ochiai Y, Kikuchi D, Koseki M, Ohashi K, Hoteya S. Long-term Outcome of Asymptomatic Esophageal Eosinophilia. Gut Liver. 2024 Jul 15;18(4):632-641.
75. Kim JP, Weingart G, Hiramoto B, Gregory DL, Gonsalves N, Hirano I. Clinical outcomes of adults with eosinophilic esophagitis with severe stricture. Gastrointest Endosc. 2020 Jul;92(1):44-53. Doi: 10.1016/j.gie.2020.01.015.
76. Hirano I, Chan ES, Rank MA, Sharaf RN, Stollman NH, Stukus DR, Wang K, Greenhawt M, Falck-Ytter YT; AGA Institute Clinical Guidelines Committee; Joint Task Force on Allergy-Immunology Practice Parameters. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis. Gastroenterology. 2020 May;158(6):1776-1786. Doi: 10.1053/j.gastro.2020.02.038.
77. Dickerson A, Dellon ES, Aceves SS. Future of therapy and monitoring for eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Ann Allergy Asthma Immunol. 2025 May 18:S1081-1206(25)00242-X. Doi: 10.1016/j.anai.2025.05.016.
78. Cotton C.C., Moist S.E., McGee S.J., Furuta G.T., Aceves S.S., Dellon ES.: A Newly Proposed Severity Index for Eosinophilic Esophagitis is Associated With Baseline Clinical Features and Successful Treatment Response. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2023 Sep; 21: pp. 2534-2542. e1.
79. Ghisa M, Laserra G, Maniero D, Marabotto E, Barberio B, Pelizzaro F, Barbuscio I, Zingone F, Savarino V, Savarino E. Eosinophilic esophagitis: from pathophysiology to management. Minerva Gastroenterol (Torino). 2022 Mar;68(1):40-48. Doi: 10.23736/S2724-5985.20.02780-4.
80. Fernandez-Becker NQ. Eosinophilic Esophagitis: Incidence, Diagnosis, Management, and Future Directions. Gastroenterol Clin North Am. 2021 Dec;50(4):825-841. Doi: 10.1016/j.gtc.2021.08.001.
81. de Rooij W.E., Dellon E.S., Parker C.E., et. al.: Pharmacotherapies for the treatment of eosinophilic esophagitis: state of the art review. Drugs 2019; 79: pp. 1419-1434.
82. Borrelli O, Ruggiero C, Alfano G, Jackman L, Russo G, Volpe D, Gaynor E, Goh L, Oliva S. Eosinophilic esophagitis in children: new kids on the block. Expert Opin Pharmacother. 2025 Jun 9. Doi: 10.1080/14656566.2025.2517801.
83. Uchida AM, Burk CM, Rothenberg ME, Furuta GT, Spergel JM. Recent Advances in the Treatment of Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2023 Sep;11(9):2654-2663. Doi: 10.1016/j.jaip.2023.06.035. Epub 2023 Jun 28.
84. Odiase E, Zhang X, Chang Y, Nelson M, Balaji U, Gu J, et al. In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump. Gastroenterology. 2021;160(6):2072–88 e6
85. Rochman M, Xie YM, Mack L, Caldwell JM, Klingler AM, Osswald GA, et al. Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors. J Allergy Clin Immunol. 2021;147(5):1924–35.
86. Thakkar KP, Fowler M, Keene S, Iuga A, Dellon ES. Long-term efficacy of proton pump inhibitors as a treatment modality for eosinophilic esophagitis. Dig Liver Dis. 2022;54(9):1179–85.
87. Visaggi P, Baiano Svizzero F, Del Corso G, Bellini M, Savarino E, de Bortoli N. Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy. Am J Gastroenterol. 2022;117(10):1702–5.
88. Musburger BG, Gonzalez Echeandia M, Suskind EL, Suskind DL, Zheng HB, Mark D. Current and Emerging Therapies for Eosinophilic Esophagitis (EoE): A Comprehensive Review. Pharmaceutics. 2025 Jun 7;17(6):753. Doi: 10.3390/pharmaceutics17060753
89. Choi HH. Eosinophilic Esophagitis: Emerging Insights Into Diagnosis and Management. Korean J Helicobacter Up Gastrointest Res. 2025 jun;25(2):117-125. Doi: 10.7704/kjhugr.2025.0013.
90. Kliewer KL, Gonsalves N, Dellon ES, et al. One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial. Lancet Gastroenterol Hepatol. 2023; 8:408–421. Doi: 10.1016/S2468-1253(23)00012-2
91. Syverson EP, Hait EJ. Treatment for eosinophilic esophagitis. Curr Opin Gastroenterol. 2020 Nov;36(6):485-490. Doi: 10.1097/MOG.000000000000068.
92. Franciosi JP, Gordon M, Sinopoulou V, Dellon ES, Gupta SK, Reed CC, Gutiérrez-Junquera C, Venkatesh RD, Erwin EA, Egiz A, Elleithy A, Mougey EB. Medical treatment of eosinophilic esophagitis. Cochrane Database Syst Rev. 2023 Jul 20;7(7):CD004065. Doi: 10.1002/14651858.CD004065.pub4.
93. Ridolo E, Barone A, Ottoni M, Peveri S, Montagni M, Nicoletta F. The New Therapeutic Frontiers in the Treatment of Eosinophilic Esophagitis: Biological Drugs. Int J Mol Sci. 2024 Jan 30;25(3):1702. Doi: 10.3390/ijms25031702.
94. Dipasquale V, Romano C. New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review. Healthcare (Basel). 2025 Apr 17;13(8):923. Doi: 10.3390/healthcare13080923.
95. Dellon ES. Monitoring of Maintenance Therapy in Eosinophilic Esophagitis: Listen, Look, and Touch. Dig Dis Sci. 2025 Mar;70(3):882-884. Doi: 10.1007/s10620-024-08819-6
96. von Arnim U, Biedermann L, Aceves SS et al. Monitoring patients with eosinophilic esophagitis in routine clinical practice - international expert recommendations. Clin Gastroenterol Hepatol. 2023;21:2526–2533.
97. Aceves SS, Alexander JA, Baron TH et al. Endoscopic approach to eosinophilic esophagitis: American Society for Gastrointestinal Endoscopy Consensus Conference. Gastrointest Endosc. 2022;96:576–92.e1 (Epub 2022/08/15).
98. Dellon ES, Muir AB, Katzka DA et al. ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. Am J Gastroenterol: In press; 2025.
99. Chang NC, Thakkar KP, Ketchem CJ, Eluri S, Reed CC, Dellon ES. A Gap in Care Leads to Progression of Fibrosis in Eosinophilic Esophagitis Patients. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1701-1708.e2. Doi: 10.1016/j.cgh.2021.10.028
100. Lucendo AJ, Molina-Infante J. Current treatment options and long-term outcomes in patients with eosinophilic esophagitis. Expert Rev Clin Immunol. 2022 Aug;18(8):859-872. Doi: 10.1080/1744666X.2022.2096591
2. Horwitz A, Yunus S. Eosinophilic Esophagitis: A Review for the Primary Care Practitioner. Med Clin North Am. 2024 Jul;108(4):733-745. Doi: 10.1016/j.mcna. 2023.08.010.
3. Dellon ES, Muir AB, Katzka DA, Shah SC, Sauer BG, Aceves SS, Furuta GT, Gonsalves N, Hirano I. ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. Am J Gastroenterol. 2025 Jan 1;120(1):31-59. Doi: 10.14309/ajg.000000000 0003194. Epub 2025 Jan 2.
4. Allin KH, Poulsen G, Melgaard D, Frandsen LT, Jess T, Krarup AL. Eosinophilic oesophagitis in Denmark: Population-based incidence and prevalence in a nationwide study from 2008 to 2018. United European Gastroenterol J. 2022 Sep;10(7):640-650. Doi: 10.1002/ueg2.12273. Epub 2022 Sep 15. PMID: 36106558;
5. Garber JJ, Lochhead PJ, Uchida AM, Roelstraete B, Bergman D, Clements MS, Ludvigsson JF. Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study. Esophagus. 2022 oct;19(4):535-541. Doi: 10.1007/s10388-022-00926-5. Epub 2022 Jun 2
6. Sawada A, Imai T, Ihara Y, Tanaka F, Hirano I, Fujiwara Y. Epidemiology and Risk Factors of Eosinophilic Esophagitis in Japan: A Population-Based Study. Clin Gastroenterol Hepatol. 2024 oct;22(10):2023-2032.e6. Doi: 10.1016/j.cgh.2024.04.035.
7. Roussel JM, Pandit S. Eosinophilic Esophagitis. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29083829
8. Gautam Y, Caldwell J, Kottyan L, Chehade M, Dellon ES, Rothenberg ME, Mersha TB; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) investigators. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. J Allergy Clin Immunol. 2023 May;151(5):1337-1350. Doi: 10.1016/j.jaci.2022. 09.040.
9. Muir A, Falk GW. Eosinophilic Esophagitis: A Review. JAMA. 2021 oct 5;326(13):1310-1318. Doi: 10.1001/jama.2021.14920
10. Thel HL, Anderson C, Xue AZ, Jensen ET, Dellon ES. Prevalence and Costs of Eosinophilic Esophagitis in the United States. Clin Gastroenterol Hepatol. 2025 feb;23(2):272-280.e8. Doi: 10.1016/j.cgh.2024.09. 03.
11. Gratacós Gómez AR, Gómez Torrijos E. Eosinophilic Esophagitis due to Aeroallergens: A Systematic Review and Update. J Investig Allergol Clin Immunol. 2022 Dec 15;32(6):438-450. Doi: 10.18176/jiaci.0853.
12. Lehman HK, Lam W. Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2021 Nov;41(4):587-598. Doi: 10.1016/j.iac.2021.07.011.
13. Patel RV, Hirano I, Gonsalves N. Eosinophilic Esophagitis: Etiology and Therapy. Annu Rev Med. 2021 Jan 27; 72:183-197. Doi: 10.1146/annurev-med-052819-023848.
14. Kennedy KV, Muir AB, Ruffner MA. Pathophysiology of Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2024 May;44(2):119-128. Doi: 10.1016/j.iac.2023.12.001.
15.Ji R, Cui X, Zhi Y. Eosinophilic esophagitis and allergic susceptibility: A systematic review and meta-analysis. World Allergy Organ J. 2025 Apr 25;18(5):101054. Doi: 10.1016/j.waojou.2025.101054
16. Alkhowaiter S. Eosinophilic esophagitis. Saudi Med J. 2023 Jul;44(7):640-646. Doi: 10.15537/smj.2023. 44.7.20220812.
17. Arias Á, Lucendo AJ. Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice. Expert Rev Gastroenterol Hepatol. 2019 Feb;13(2):99-117. Doi: 10.1080/17474124.2019.1546120
18. Fernandez-Becker NQ, Raja S, Scarpignato C, Lynch KL, Ahuja NK, Horsley-Silva JL. Eosinophilic esophagitis: updates on key unanswered questions. Ann N Y Acad Sci. 2020 Dec;1481(1):30-42. Doi: 10.1111/nyas. 14421
19. Lim AH, Wong S, Nguyen NQ. Eosinophilic Esophagitis and IgG4: Is There a Relationship? Dig Dis Sci. 2021 Dec;66(12):4099-4108. Doi: 10.1007/s10620-020-06788-0.
20. McGowan EC, Singh R, Katzka DA. Barrier Dysfunction in Eosinophilic Esophagitis. Curr Gastroenterol Rep. 2023 Dec;25(12):380-389. Doi: 10.1007/s11894-023-00904-6. Epub 2023 Nov 11
21. Underwood B, Troutman TD, Schwartz JT. Breaking down the complex pathophysiology of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2023 Jan;130(1):28-39. Doi: 10.1016/j.anai.2022.10.026.
22. Sciumè GD, Visaggi P, Sostilio A, et al. Esofagitis eosinofílica: nuevos conceptos sobre patogénesis y manifestaciones clínicas. Minerva Gastroenterology. Marzo de 2022;68(1):23-39. DOI: 10.23736/s2724-5985.20.02807-x.
23. de Bortoli N, Visaggi P, Penagini R, Annibale B, Baiano Svizzero F, Barbara G, Bartolo O, Battaglia E, Di Sabatino A, De Angelis P, Docimo L, Frazzoni M, Furnari M, Iori A, Iovino P, Lenti MV, Marabotto E, Marasco G, Mauro A, Oliva S, Pellegatta G, Pesce M, Privitera AC, Puxeddu I, Racca F, Ribolsi M, Ridolo E, Russo S, Sarnelli G, Tolone S, Zentilin P, Zingone F, Barberio B, Ghisa M, Savarino EV. The 1st EoETALY Consensus on the Diagnosis and Management of Eosinophilic Esophagitis - Definition, Clinical Presentation and Diagnosis. Dig Liver Dis. 2024 jun;56(6):951-963. Doi: 10.1016/j.dld.2024.02.005.
24. Visaggi P, Savarino E, Sciume G, Chio TD, Bronzini F, Tolone S, Frazzoni M, Pugno C, Ghisa M, Bertani L, Bellini M, Savarino V, Peroni D, Marchi S, de Bortoli N. Eosinophilic esophagitis: clinical, endoscopic, histologic and therapeutic differences and similarities between children and adults. Therap Adv Gastroenterol. 2021 Jan 31; 14:1756284820980860. Doi: 10.1177/ 1756284820980860.
25. Xu X, Kwiatek J, Siddall J, Genofre E, Stirnadel-Farrant H, Katial R. Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-world clinical practice. BMC Gastroenterol. 2024 Aug 3;24(1):246. Doi: 10.1186/s12876-024-03334-4
26. Taft TH, Carlson DA, Simons M, Zavala S, Hirano I, Gonsalves N, Pandolfino JE. Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis. Gastroenterology. 2021 Oct;161(4):1133-1144. Doi: 10.1053/j.gastro.2021.06.023. Epub 2021 Jun 19. PMID: 34153298.
27. Chang JW, Chen VL, Rubenstein JH, Dellon ES, Wallner LP, De Vries R. What patients with eosinophilic esophagitis may not share with their providers: a qualitative assessment of online health communities. Dis Esophagus. 2022 Jun 15;35(6):doab073. Doi: 10.1093/dote/doab073
28. Gold BD, Goodwin B, Davis K, Sweeney C, Reynolds M, Jiang J, Fan T, Boules M, Chen ST, Katzka DA. Health-Related Quality of Life and Perceived Stigma in Eosinophilic Esophagitis: A Real-World, US, Web-Based Survey. Gastro Hep Adv. 2024 Jul 30;3(8):1087-1097. Doi: 10.1016/j.gastha.2024.07.015
29. Rooij WE, Evertsz FB, Lei A, Bredenoord AJ. General Well-being and Coping Strategies in Adult Eosinophilic Esophagitis Patients. J Neurogastroenterol Motil. 2022 Jul 30;28(3):390-400. Doi: 10.5056/jnm21143.
30. Schreiner P, Safroneeva E, Rossel JB, Limacher A, Saner C, Greuter T, Schoepfer A, Straumann A, Biedermann L. Sex Impacts Disease Activity But Not Symptoms or Quality of Life in Adults With Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1729-1738.e1. Doi: 10.1016/j.cgh.2021.11.009.
31. Meyer R, Cianferoni A, Vazquez-Ortiz M. An update on the diagnosis and management of non-IgE-mediated food allergies in children. Pediatr Allergy Immunol. 2025 Mar;36(3):e70060. Doi: 10.1111/pai.70060. PMID: 40110885.
32. Hoerning A, Steiss JO, Madisch A, de Laffolie J. Eosinophilic Esophagitis: Prevalence, Diagnosis, and Treatment in Childhood and Adulthood. Dtsch Arztebl Int. 2025 Apr 4;(Forthcoming): arztebl.m2025.0042. Doi: 10.3238/arztebl.m2025.0042
33. O'Shea D, Quinn E, Middlesworth W, Khlevner J. Diagnosis and Management of Long-term Gastrointestinal Complications in Pediatric Esophageal Atresia/Tracheoesophageal Fistula. Curr Gastroenterol Rep. 2025 Feb 25;27(1):16. Doi: 10.1007/s11894-025-00968-6.
34. Farah A, Assaf T, Hindy J, Abboud W, Mahamid M, Savarino EV, Mari A. The Dynamic Evolution of Eosinophilic Esophagitis. Diagnostics (Basel). 2025 Jan 21;15(3):240. Doi: 10.3390/diagnostics15030240.
35. Barchi A., Vespa E., Passaretti S., Dell’anna G., Fasulo E., Yacoub M.-R., Albarello L., Sinagra E., Massimino L., Ungaro F., et al. The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders-A Comprehensive Review. Diagnostics. 2024; 14:858. Doi: 10.3390/diagnostics14080858
36. de Bortoli N., Visaggi P., Penagini R., Annibale B., Svizzero F.B., Barbara G., Bartolo O., Battaglia E., Di Sabatino A., De Angelis P., et al. The 1st EoETALY Consensus on the Diagnosis and Management of Eosinophilic Esophagitis—Current Treatment and Monitoring. Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver. 2024; 56:1173–1184. Doi: 10.1016/j.dld.2024.02.020.
37. Gupta M, Grinman M. Diagnosis and management of eosinophilic esophagitis. CMAJ. 2024 feb 4;196(4): E121-E128. Doi: 10.1503/cmaj.230378
38.Papadopoulou A., Amil-Dias J., Auth M.K.H., Chehade M., Collins M.H., Gupta S.K., et al. Joint ESPGHAN/NASPGHAN guidelines on childhood eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2024; 78:122–152. Doi: 10.1097/MPG.0000000000003877.
39. Gonzalez-Uribe V, Hernandez-Zarate LA, Pozo Beltran CF, Alcocer-Arreguin CR, de Baro Alvarez P, Coello-Niembro N, Jimenez-Feria P, Mojica Gonzalez ZS, Gomez-Nuñez CA, Martinez-Tenopala R, Basile-Alvarez MR, Velasco-Benhumea B, Fernandez-Soto R, García-Fajardo DE, Perez-Avilés H, Pinto-Solis C, Rios-Villalobos LA, Ureña-Ortiz R, Lezama-Vazquez L, Acosta-Rodriguez-Bueno P, Del Rio-Navarro BE. Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico. J Allergy Clin Immunol Glob. 2024 Dec 18;4(1):100392. Doi: 10.1016/j.jacig.2024.100392
40. Almazan E, Liang TZ, Hohl B, Hoskins BJ, Birkness-Gartman JE, Ng K. EndoFLIP distensibility index correlates with histologic findings in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2025 May;80(5):824-831. Doi: 10.1002/jpn3.70013.
41. Lin B, Rabinowitz S, Haseeb MA, Gupta R. Usefulness of the eosinophilic esophagitis histologic scoring system in distinguishing active eosinophilic esophagitis from remission and gastroesophageal reflux disease. Gastroenterol Res. 2021; 14(4): 220-226.
42. Hoffmann NV, Keeley K, Wechsler JB. Esophageal distensibility defines fibrostenotic severity in pediatric eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2023; 21: 1188-1197.e4. Doi:10.1016/j.cgh.2022.08.044
43. Sykes C.M., Fairlamb G.M., Fox M.M., Sweis R. Assessment of Esophageal Motility in Patients With Eosinophilic Esophagitis: A Scoping Review. J. Clin. Gastroenterol. 2023;57:10–30. Doi: 10.1097/MCG.0000000000001792.
44. Nguyen N, Lavery WJ, Capocelli KE, Smith C, DeBoer EM, Deterding R, Prager JD, Leinwand K, Kobak GE, Kramer RE, Menard-Katcher C, Furuta GT, Atkins D, Fleischer D, Greenhawt M, Friedlander JA. Transnasal Endoscopy in Unsedated Children With Eosinophilic Esophagitis Using Virtual Reality Video Goggles. Clin Gastroenterol Hepatol. 2019 nov;17(12):2455-2462. Doi: 10.1016/j.cgh.2019.01.023. Epub 2019 Jan 29.
45. Visaggi P, Solinas I, Baiano Svizzero F, Bottari A, Barberio B, Lorenzon G, Ghisa M, Maniero D, Marabotto E, Bellini M, de Bortoli N, Savarino EV. Non-Invasive and Minimally Invasive Biomarkers for the Management of Eosinophilic Esophagitis beyond Peak Eosinophil Counts: Filling the Gap in Clinical Practice. Diagnostics (Basel). 2023 Aug 30;13(17):2806. Doi: 10.3390/diagnostics13172806.
46. Sebastian-Delacruz M, Garcia-Etxebarria K, Bilbao JR, Lucendo AJ, Bujanda L, Castellanos-Rubio A. A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels. Clin Gastroenterol Hepatol. 2024 Mar;22(3):656-658.e3. Doi: 10.1016/j.cgh.2023.07.023.
47. Fass OZ, Clarke JO. Reflux, eosinophilic esophagitis, and celiac disease - the blurred lines. Curr Opin Otolaryngol Head Neck Surg. 2024 Dec 1;32(6):367-373. Doi: 10.1097/MOO.0000000000000989.
48. Hussein M, Mitchison M, Sweis R. Lymphocytic oesophagitis: diagnosis and management. Clin Med (Lond). 2023 nov;23(6):540-544. Doi: 10.7861/clinmed.2023-0440.
49. Resende F, Ferrão A, Melo R, Barbosa E Sr, Barbosa A. A New Differential Diagnosis of Dysphagia: A Case Report of Lymphocytic Esophagitis. Cureus. 2021 Jan 30;13(1):e13010. Doi: 10.7759/cureus.13010.
50. Avila M, Ambelil M, Tong Y, Khurana S, Abraham F, Ertan A, Thosani NC, DuPont AW, Cash BD, Younes M. Lymphocytic Esophagitis Is Not Similar to Eosinophilic Esophagitis Except for Seasonal Variation. Ann Clin Lab Sci. 2021 May;51(3):347-351.
51. Jradi A, Khoury KM, Karam K, El Hajj DII, Fiani E. Lymphocytic Esophagitis: Navigating an Uncharted Territory. J Investig Med High Impact Case Rep. 2025 Jan-Dec; 13:23247096251313734. Doi: 10.1177/23247096251313734.
52. Khan S, Guo X, Liu T, Iqbal M, Jiang K, Zhu L, Chen X, Wang BM. An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications. Digestion. 2021;102(3):342-356. Doi: 10.1159/000508191.
53. Gratacós Gómez AR, Meneses Sotomayor JV, Joyanes Romo JB, Palacios Cañas A, Gonzalez Lopez L, Gomez Torrijos E. Symptoms and complications that require urgent treatment and upper digestive comorbidities in eosinophilic esophagitis. Dig Liver Dis. 2022 Jun;54(6):842-844. Doi: 10.1016/j.dld.2022.03.015. Epub 2022 Apr 11.
54. Khan S, Guo X, Liu T, Iqbal M, Jiang K, Zhu L, Chen X, Wang BM. An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications. Digestion. 2021;102(3):342-356. Doi: 10.1159/000508191.
55. Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology. 2022 Jul;163(1):59-76. Doi: 10.1053/j.gastro.2022.03.025.
56. Issa D, Alwatari Y, Smallfield GB, Shah RD. Spontaneous transmural perforation in eosinophilic esophagitis: RARE case presentation and role of esophageal stenting. J Surg Case Rep. 2019 Jun 14;2019(6):rjz190. Doi: 10.1093/jscr/rjz190
57. Fianchi F, De Matteis G, Cianci R, Pizzoferrato M, Cardone S, Nicolazzi MA, Fuorlo M, Congedo MT, Arena V, Riccioni ME, Barbaro B, Gambassi G. Acute intramucosal dissection in eosinophilic esophagitis. Clin J Gastroenterol. 2019 Dec;12(6):525-529. Doi: 10.1007/s12328-019-00990.
58. Bose, P., Kumar, S., Nebesio, T. D., Li, C., Hon, E. C., Atkins, D., Furuta G. T, Gupta, S. K. Adrenal insufficiency in children with eosinophilic esophagitis treated with topical corticosteroids. Journal of Pediatric Gastroenterology and Nutrition. 2020. 70(3), 324-329.
59. Redd WD, Ocampo AA, Xue Z, Chang NC, Thakkar KP, Reddy SB, Greenberg SB, Lee CJ, Ketchem CJ, Eluri S, Reed CC, Dellon ES. Eosinophilic esophagitis patients with multiple atopic conditions: Clinical characteristics and treatment response topical steroids. Ann Allergy Asthma Immunol. 2023 Jul;131(1):109-115.e2. Doi: 10.1016/j.anai.2023.04.026.
60. Capucilli P, Hill DA. Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications. Clin Rev Allergy Immunol. 2019 Aug;57(1):111-127. Doi: 10.1007/s12016-019-08733-0.
61. Jaros J, Ahuja K, Lio P. Exploring the Link Between Atopic Dermatitis and Eosinophilic Esophagitis. J Clin Aesthet Dermatol. 2025 Mar;18(3):15-20. PMID: 40135176.
62. Burk CM, Shreffler WG. Triggers for eosinophilic esophagitis (EoE): The intersection of food allergy and EoE. J Allergy Clin Immunol. 2024 Jun;153(6):1500-1509. Doi: 10.1016/j.jaci.2024.04.010.
63. Gabryszewski SJ, Dudley J, Shu D, Faerber JA, Grundmeier RW, Fiks AG, et al. Patrones en el desarrollo de la alergia pediátrica. Pediatría 2023;152.
64. Cafone J, Capucilli P, Hill DA, Spergel JM. Eosinophilic esophagitis during sublingual and oral allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):350-357. Doi: 10.1097/ACI.0000000000000537.
65. Jin H, Trogen B, Nowak-Wegrzyn A. Eosinophilic esophagitis as a complication of food oral immunotherapy. Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):616-623. Doi: 10.1097/ACI.0000000000000688.
66. Gratacós Gómez AR, Meneses Sotomayor JV, Joyanes Romo JB, Palacios Cañas A, Gonzalez Lopez L, Gomez Torrijos E. Symptoms and complications that require urgent treatment and upper digestive comorbidities in eosinophilic esophagitis. Dig Liver Dis. 2022 Jun;54(6):842-844. Doi: 10.1016/j.dld.2022.03.015.
67. Wojas O, Krzych-Fałta E, Żybul P, Żalikowska-Gardocka M, Ilczuk T, Furmańczyk K, Samoliński B, Przybyłkowski A. The Overlap of Allergic Disorders and Upper Gastrointestinal Symptoms: Beyond Eosinophilic Esophagitis. Nutrients. 2025 Apr 16;17(8):1355. Doi: 10.3390/nu17081355..
68. Ketchem CJ, Starling AS. Insights into the natural history and disease course of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2025 Mar 29:S1081-1206(25)00154-1. Doi: 10.1016/j.anai.2025.03.019.
69. Molina-Infante J, Rodríguez-Lago I. Modifying the natural history of gastrointestinal diseases in Europe as a result of early diagnosis: From eosinophilic esophagitis to inflammatory bowel disease. United European Gastroenterol J. 2022 Sep;10(7):612-613. Doi: 10.1002/ueg2.12256. Epub 2022 May 25.
70. Strauss Starling A, Ren Y, Li H, Spergel JM, Muir AB, Lynch KL, Liacouras CA, Falk GW. Reducing Eosinophil Counts in Eosinophilic Esophagitis in Children Is Associated With Reduction in Later Stricture Development. Am J Gastroenterol. 2024 Oct 1;119(10):2002-2009. Doi: 10.14309/ajg.0000000000002830
71. Wong S, Ellison S, Haj Ali S, Hawkes J, Collinson J, O'Neill T, Ruszkiewicz A, Moore D, Holloway RH, Nguyen NQ. Characteristics and progression of childhood-onset and adult-onset eosinophilic esophagitis. J Gastroenterol Hepatol. 2022 Jan;37(1):69-74. Doi: 10.1111/jgh.15660.
72. McGowan EC, Wright BL, Ruffner MA, Pesek RD, Rothenberg ME, Spergel JM, Dellon ES, Aceves SS. Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines. J Allergy Clin Immunol. 2025 May 6:S0091-6749(25)00510-X. Doi: 10.1016/j.jaci.2025.04.026.
73. Abe Y, Kikuchi R, Sasaki Y, Mizumoto N, Yagi M, Onozato Y, Watabe T, Goto H, Miura T, Sato R, Ito M, Tsuchiya H, Ueno Y. Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis. Endosc Int Open. 2024 Apr 15;12(4):E545-E553. Doi: 10.1055/a-2280-8277.
74. Suzuki Y, Ochiai Y, Kikuchi D, Koseki M, Ohashi K, Hoteya S. Long-term Outcome of Asymptomatic Esophageal Eosinophilia. Gut Liver. 2024 Jul 15;18(4):632-641.
75. Kim JP, Weingart G, Hiramoto B, Gregory DL, Gonsalves N, Hirano I. Clinical outcomes of adults with eosinophilic esophagitis with severe stricture. Gastrointest Endosc. 2020 Jul;92(1):44-53. Doi: 10.1016/j.gie.2020.01.015.
76. Hirano I, Chan ES, Rank MA, Sharaf RN, Stollman NH, Stukus DR, Wang K, Greenhawt M, Falck-Ytter YT; AGA Institute Clinical Guidelines Committee; Joint Task Force on Allergy-Immunology Practice Parameters. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis. Gastroenterology. 2020 May;158(6):1776-1786. Doi: 10.1053/j.gastro.2020.02.038.
77. Dickerson A, Dellon ES, Aceves SS. Future of therapy and monitoring for eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Ann Allergy Asthma Immunol. 2025 May 18:S1081-1206(25)00242-X. Doi: 10.1016/j.anai.2025.05.016.
78. Cotton C.C., Moist S.E., McGee S.J., Furuta G.T., Aceves S.S., Dellon ES.: A Newly Proposed Severity Index for Eosinophilic Esophagitis is Associated With Baseline Clinical Features and Successful Treatment Response. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2023 Sep; 21: pp. 2534-2542. e1.
79. Ghisa M, Laserra G, Maniero D, Marabotto E, Barberio B, Pelizzaro F, Barbuscio I, Zingone F, Savarino V, Savarino E. Eosinophilic esophagitis: from pathophysiology to management. Minerva Gastroenterol (Torino). 2022 Mar;68(1):40-48. Doi: 10.23736/S2724-5985.20.02780-4.
80. Fernandez-Becker NQ. Eosinophilic Esophagitis: Incidence, Diagnosis, Management, and Future Directions. Gastroenterol Clin North Am. 2021 Dec;50(4):825-841. Doi: 10.1016/j.gtc.2021.08.001.
81. de Rooij W.E., Dellon E.S., Parker C.E., et. al.: Pharmacotherapies for the treatment of eosinophilic esophagitis: state of the art review. Drugs 2019; 79: pp. 1419-1434.
82. Borrelli O, Ruggiero C, Alfano G, Jackman L, Russo G, Volpe D, Gaynor E, Goh L, Oliva S. Eosinophilic esophagitis in children: new kids on the block. Expert Opin Pharmacother. 2025 Jun 9. Doi: 10.1080/14656566.2025.2517801.
83. Uchida AM, Burk CM, Rothenberg ME, Furuta GT, Spergel JM. Recent Advances in the Treatment of Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2023 Sep;11(9):2654-2663. Doi: 10.1016/j.jaip.2023.06.035. Epub 2023 Jun 28.
84. Odiase E, Zhang X, Chang Y, Nelson M, Balaji U, Gu J, et al. In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump. Gastroenterology. 2021;160(6):2072–88 e6
85. Rochman M, Xie YM, Mack L, Caldwell JM, Klingler AM, Osswald GA, et al. Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors. J Allergy Clin Immunol. 2021;147(5):1924–35.
86. Thakkar KP, Fowler M, Keene S, Iuga A, Dellon ES. Long-term efficacy of proton pump inhibitors as a treatment modality for eosinophilic esophagitis. Dig Liver Dis. 2022;54(9):1179–85.
87. Visaggi P, Baiano Svizzero F, Del Corso G, Bellini M, Savarino E, de Bortoli N. Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy. Am J Gastroenterol. 2022;117(10):1702–5.
88. Musburger BG, Gonzalez Echeandia M, Suskind EL, Suskind DL, Zheng HB, Mark D. Current and Emerging Therapies for Eosinophilic Esophagitis (EoE): A Comprehensive Review. Pharmaceutics. 2025 Jun 7;17(6):753. Doi: 10.3390/pharmaceutics17060753
89. Choi HH. Eosinophilic Esophagitis: Emerging Insights Into Diagnosis and Management. Korean J Helicobacter Up Gastrointest Res. 2025 jun;25(2):117-125. Doi: 10.7704/kjhugr.2025.0013.
90. Kliewer KL, Gonsalves N, Dellon ES, et al. One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial. Lancet Gastroenterol Hepatol. 2023; 8:408–421. Doi: 10.1016/S2468-1253(23)00012-2
91. Syverson EP, Hait EJ. Treatment for eosinophilic esophagitis. Curr Opin Gastroenterol. 2020 Nov;36(6):485-490. Doi: 10.1097/MOG.000000000000068.
92. Franciosi JP, Gordon M, Sinopoulou V, Dellon ES, Gupta SK, Reed CC, Gutiérrez-Junquera C, Venkatesh RD, Erwin EA, Egiz A, Elleithy A, Mougey EB. Medical treatment of eosinophilic esophagitis. Cochrane Database Syst Rev. 2023 Jul 20;7(7):CD004065. Doi: 10.1002/14651858.CD004065.pub4.
93. Ridolo E, Barone A, Ottoni M, Peveri S, Montagni M, Nicoletta F. The New Therapeutic Frontiers in the Treatment of Eosinophilic Esophagitis: Biological Drugs. Int J Mol Sci. 2024 Jan 30;25(3):1702. Doi: 10.3390/ijms25031702.
94. Dipasquale V, Romano C. New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review. Healthcare (Basel). 2025 Apr 17;13(8):923. Doi: 10.3390/healthcare13080923.
95. Dellon ES. Monitoring of Maintenance Therapy in Eosinophilic Esophagitis: Listen, Look, and Touch. Dig Dis Sci. 2025 Mar;70(3):882-884. Doi: 10.1007/s10620-024-08819-6
96. von Arnim U, Biedermann L, Aceves SS et al. Monitoring patients with eosinophilic esophagitis in routine clinical practice - international expert recommendations. Clin Gastroenterol Hepatol. 2023;21:2526–2533.
97. Aceves SS, Alexander JA, Baron TH et al. Endoscopic approach to eosinophilic esophagitis: American Society for Gastrointestinal Endoscopy Consensus Conference. Gastrointest Endosc. 2022;96:576–92.e1 (Epub 2022/08/15).
98. Dellon ES, Muir AB, Katzka DA et al. ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. Am J Gastroenterol: In press; 2025.
99. Chang NC, Thakkar KP, Ketchem CJ, Eluri S, Reed CC, Dellon ES. A Gap in Care Leads to Progression of Fibrosis in Eosinophilic Esophagitis Patients. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1701-1708.e2. Doi: 10.1016/j.cgh.2021.10.028
100. Lucendo AJ, Molina-Infante J. Current treatment options and long-term outcomes in patients with eosinophilic esophagitis. Expert Rev Clin Immunol. 2022 Aug;18(8):859-872. Doi: 10.1080/1744666X.2022.2096591