Home > Medical Research Archives > Issue 149 > Attenuating the coagulation cascade with annexin A5
Published in the Medical Research Archives
Jul 2015 Issue
Attenuating the coagulation cascade with annexin A5
Published on Jul 11, 2015
DOI
Abstract
Membrane displayed phosphatidylserine (PS) on platelets, microparticles, endothelial cells and erythrocytes is the platform for the coagulation cascade and annexin A5’s great affinity for PS allows it to bind to it and form a shield that can block the cascade. In spite of this significant anticoagulant ability annexin A5 has no therapeutic anticoagulant application. Why?
Author info
James Kennedy
Author Area
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