Increasing heart failure (HF) patients draw worldwide concern. In the current aging society, the incidence of HF preserved ejection fraction (HFpEF) has been increasing and hypertension is one of inducible causations of HFpEF. In addition, higher blood pressure (BP) is associated with a sudden onset of acute vascular insufficiency in HFpEF. Therefore, an optimal control of BP is essential in HF management, particularly in HFpEF. However, it is often not practically possible to increase the dosage of antihypertensive medications for an optimal control of BP. Antihypertensive medications often cause orthostatic hypotension (OH). Choosing a medication with the difference of the half-life of the medication and the onset of action in mind is one of these solution methods. We revealed bisoprolol transdermal patch improves OH in patients with chronic heart failure and hypertension, compared with bisoprolol fumarate tablet. Herein, we focus on the importance of a management of BP in the HF treatment based on the clinical evidence, including our results.