Cases of keratitis associated with herpes zoster or varicella vaccine are rare. A review from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization yielded only 24 cases of unilateral keratitis that occured within days of vaccination and resolved with topical steroid drops and oral acyclovir. The mechanism of such event seems to be the persistence of viral antigens in the cornea after varicella vaccination or herpes zoster ophthalmicus.
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