Polycations. XXIV. Approaches to Polycationic Alternatives to Antibiotics

Abstract

Efforts toward the development of polycationic lipid materials as alternative approaches for control of pathogenic bacteria continue. Herein are described several carbohydrate scaffolding systems for the covalent attachment of cationic lipids to provide clusters of sites capable of disrupting the pathogenic bacterial cells. Studies with S. aureus and E. coli are reported.