Relation of Resistin, Visfatin, and Carotid Intima-Media Thickness to Metabolic Syndrome and Insulin Resistance in Egyptian Rheumatoid Arthritis Patients
Main Article Content
Abstract
Introduction
Adipocytokines are hormones secreted by adipose tissue, playing a significant role in the pathogenesis of the immune response in rheumatoid arthritis (RA).
Objective
We investigated the changes in resistin, visfatin, and carotid intima-media thickness (CIMT) in rheumatoid arthritis patients and their relationships to metabolic syndrome and insulin resistance.
Research design and methodology
We studied 140 subjects: 70 with RA, 41 patients with metabolic syndrome (MetS), 29 without MetS, and 70 controls. We compared levels of resistin, visfatin, and CIMT among the three groups.
Results
There was an increase in the means of all parameters of MetS. Visfatin and CIMT increased in cases compared to the control group. There was an add-on effect of MetS on RA.
Conclusions
Resistin, visfatin, and CIMT can be used as markers of both immune and metabolic activity in cases of RA.
Adipocytokines are hormones secreted by adipose tissue, playing a significant role in the pathogenesis of the immune response in rheumatoid arthritis (RA).
Objective
We investigated the changes in resistin, visfatin, and carotid intima-media thickness (CIMT) in rheumatoid arthritis patients and their relationships to metabolic syndrome and insulin resistance.
Research design and methodology
We studied 140 subjects: 70 with RA, 41 patients with metabolic syndrome (MetS), 29 without MetS, and 70 controls. We compared levels of resistin, visfatin, and CIMT among the three groups.
Results
There was an increase in the means of all parameters of MetS. Visfatin and CIMT increased in cases compared to the control group. There was an add-on effect of MetS on RA.
Conclusions
Resistin, visfatin, and CIMT can be used as markers of both immune and metabolic activity in cases of RA.
Article Details
How to Cite
RAOOF, Pierre et al.
Relation of Resistin, Visfatin, and Carotid Intima-Media Thickness to Metabolic Syndrome and Insulin Resistance in Egyptian Rheumatoid Arthritis Patients.
Medical Research Archives, [S.l.], v. 14, n. 4, may 2026.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7444>. Date accessed: 01 may 2026.
Keywords
Adipocytokines, Metabolic Syndrome, Rheumatoid Arthritis, Carotid Intima Media Thickness
Section
Research Articles
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