Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease
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Jun 15, 2017
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Edwin J. Forero
Sergio L. Novi
Wagner M. Avelar
Carlos A. Anjos
Julien G. Menko
Rodrigo M. Forti
Vinicius R. Oliveira
Fernando Cendes
http://orcid.org/0000-0001-9336-9568
Roberto J. M. Covolan
Rickson C. Mesquita
http://orcid.org/0000-0003-1945-6713
http://orcid.org/0000-0001-9336-9568
Roberto J. M. Covolan
Rickson C. Mesquita
http://orcid.org/0000-0003-1945-6713
Abstract
Atherosclerotic disease has been associated with increased risk of severe neurovascular consequences including transient ischemic attacks, ischemic strokes, and even mortality. Following the onset of carotid stenosis, the brain undergoes different compensatory mechanisms to provide adequate perfusion in order to maintain brain metabolism. In this study, we employed near-infrared spectroscopy (NIRS) to better comprehend how carotid stenosis affects cerebral hemodynamics, both at rest and during activity. Eighteen patients diagnosed with atherosclerotic disease were recruited for a protocol consisting of resting state and vasoreactivity testing performed with breath holding. Although the breath holding challenge induced global vasodilation in all patients, the extent of dilation varied according to the level of stenosis. Patients diagnosed with carotid stenosis have impaired hemodynamic response, with a median 77% vasoreactivity in the hemisphere ipsilateral to the stenotic vessel when compared to the healthy hemisphere. Hemodynamics of these patients differed at rest, with 33% fewer network links in the hemisphere ipsilateral to the stenosis than the healthy hemisphere. On the other hand, hemodynamic patterns were more heterogeneous with patients diagnosed with a carotid occlusion, which correlates with the opening of collateral circulation. Overall, our results suggest that NIRS can open new directions to the investigation of the effects of cerebrovascular atherosclerotic disease.
Article Details
How to Cite
FORERO, Edwin J. et al.
Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease.
Medical Research Archives, [S.l.], v. 5, n. 6, june 2017.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1240>. Date accessed: 16 dec. 2024.
Keywords
NIRS, stenosis, breath holding, functional connectivity
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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