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The bio-reducible dendrimers containing poly(ethylenimine) and disulfides are interested in gene delivery systems as carrier for gene therapy. The synthesis
and characterization of poly(ethylenimine) conjugated polymers has been reviewed for the development of gene delivery systems. The linear PEIs and branched PEIs of bio-reducible dendrimers have briefly introduced in this paper. The preparation and application of poly(ethylenimine)s conjugated bio-reducible dendrimers are also discussed for the discovery of gene delivery systems. The bio-reducible poly(ethylenimine)s dendrimers have a great potential as gene carriers in drug delivery systems. It has reported that the bio-reducible PEIs branched dendrimers have a great potential as a gene delivery system consisting of PEI (1.8kDa) with disulfide bonds.