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Home  >  Medical Research Archives  >  Issue 149  > Candida albicans; exploring glycosylation pathway in the search of targets for antimicrobial agents and yeast to hyphae transition.
Published in the Medical Research Archives
Oct 2019 Issue

Candida albicans; exploring glycosylation pathway in the search of targets for antimicrobial agents and yeast to hyphae transition.

Published on Oct 03, 2019

DOI 

Abstract

 

Microbial cell wall is mostly synthesized by the glycosylated proteins with the distinct enzymatic activity. In this review we have concentrated on the description of the certain steps of glycosylation and their effect on the cell wall integrity and yeast to hyphae transition, the process enhancing the pathogenic properties of C.albicans.

 The glycoproteins play an invaluable role in C. albicans virulence and they modulate adhesive, invasive, morphogenetic and immune stimulating properties of the pathogen as well as its susceptibility to the antifungal agents. Therefore, understanding of C. albicans glycobiology might let us expand the arsenal in the war against fungal enemies. The early stages of N-, O-glycans and GPI-anchor synthesis requires dolichol - the lipid carrier of sugar residues. Diminished supply of dolichol causes series of defects in C. albicans cells, among which aberrant protein glycosylation is the most evident. Furthermore, the relations between the cell wall composition and integrity, resistance to some antifungal and cell wall disturbing agents and dolichol dependent glycosylation are observed.  Moreover relevance of these reactions for the morphological differentiation of C.albicans is described.

Author info

Grazyna Palamarczyk, Joanna Kruszewska, Urszula Lenart, Monika Niewiadomska, Anna Janik, Anna Janik, Mateusz Juchimiuk

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