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Case: This case is presented to highlight the rare involvement of the ankle and hindfoot by myxoid chondrosarcoma. The patient was a middle aged male that was previously misdiagnosed as having PVNS in his ankle approximately 10 years earlier. He presented to our clinic after the acute onset of pain in his ankle after a therapy session for his lower back without direct trauma to the foot and was found to have a pathologic talar neck fracture Chondrosarcoma is rarely found about the ankle and foot with myxoid chondrosarcoma of the plafond, talus and calcaneus being exceedingly rare. The most common locations for chondrosarcoma are the pelvis, proximal femur, distal femur, and the shoulder girdle. There are only a few case reports of myxoid chondrosarcoma in the talus and calcaneus. Conclusion: This report reflects the importance of proper diagnosis and the consequences of misdiagnosis that ultimately resulted in below the knee amputation (BKA).