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Home  >  Medical Research Archives  >  Issue 149  > Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics
Published in the Medical Research Archives
Jan 2021 Issue

Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics

Published on Jan 28, 2021

DOI 

Abstract

 

Hyperbrached poly(ester)s derived from naturally-occurring biomonomers may serve as excellent platforms for the sustained-release of therapeutics. Those generated from glycerol are particularly attractive. Traditionally, the difference in reactivity of the hydroxyl groups of glycerol has precluded the formation of well-defined polymers at high monomer conversion without gelation. Using the Martin-Smith model to select appropriate monomer ratios (ratios of functional groups), polymerization may be carried out to high conversion while avoiding gelation and with the assurance of a single type of endgroup. Various agents may be attached via esterification, amide formation or other process. Sustained release of the active agent may be readily achieved by enzyme-catalyzed hydrolysis.

Author info

Bob Howell, Tracy Zhang, Patrick Smith

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