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Home  >  Medical Research Archives  >  Issue 149  > PD (L) 1-Inhibitors and Radiation: A Good Combination for Local and Systemic Effects?
Published in the Medical Research Archives
Jun 2021 Issue

PD (L) 1-Inhibitors and Radiation: A Good Combination for Local and Systemic Effects?

Published on Jun 14, 2021

DOI 

Abstract

 

Radiation therapy is an important component in treatment of solid tumours, in a locally advanced situation and also in a metastatic situation. Indications for using PD- (L) -1 inhibitors increase especially in the metastatic situation, but also in locally advanced solid tumours. Preclinical data show local and systemically effective synergies between local irradiation and an application of checkpoint inhibitors. In the metastatic situation, a possible abscopal effect is of particular interest. This abscopal effect can be achieved especially in concurrent approaches of PD-(L)-1-inhibitors and stereotactic radiation with higher single doses like 3 x 8 Gy or 4 x 12,5 Gy. In locally advanced tumours a local enhancement of the radiation effect, and also an abscopal effect to eliminate potential micrometastases to is of great interest to achieve healing. In this treatment situation promising results are seen in the application of PD-(L)-1-inhibitors as maintenance after concurrent chemoradiation especially in non-small cell lung cancer, as well as in concurrent applications of conventionally fractionated radiotherapy and PD-(L)-1 inhibitors. These approaches and results are considered from the clinician’s point of view.

Author info

Gunther Klautke, Klaus Pietschmann, Zohier Srour

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