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Asian American Pacific Islanders (AAPI) are the fastest growing ethnic group in the United States.  Despite such growth, AAPI face considerable challenges to HIV prevention, treatment, testing and care. The development of multilevel and multi-strategy approaches to education, prevention, and treatment requires an understanding of personal and cultural barriers, as well as implementation of culturally sensitive and specific measures.  The purpose of this article is to highlight barriers to HIV-related prevention, treatment, and care for AAPI and provide practical, application-based suggestions which may facilitate greater inclusion of AAPI in the continuum of HIV care.