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Coronavirus infection influences on multiple organs and contributes to the progression of concurrent diseases. The most notable and outstanding changes and COVID complications appear in patients with pre – existing cardiovascular and metabolic disturbances especially in elderly. There is evidence that acute viral as well as chronical diseases promote rapid cell senescence and prolong the process of recovery from disease. This review reflects the main common points and axis joining the pre-existing diseases and coronavirus infections complications and resolution. Diabetes mellitus type 2 and cardiovascular diseases (hypertension) predispose to severe outcome of the disease and the COVID-19 mortality risk. The Klotho protein level may be promising predictor of COVID severity and complications in many patients. In order to control properly the rehabilitation process and estimate the level of treatment efficacy we tried to reflect the property of milestone clue biomarker of senescence and cell damage – Klotho protein.