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With the development of increasingly sophisticated biotechnology and conceptual/analytic approaches, a greater ability to understand, intervene and prevent disease and promote health is becoming more available. A synthetic integration of several such technologies and analytic strategies named the Canary System is described which can impact significant global health problems, including the COVID-19 pandemic with its continuously evolving variants. The system wirelessly acquires high fidelity heart rate variability and other data, geocodes the data and transfers It through personal device for high throughput algorithmic analysis, which has been shown to indicate likely COVID-19 status well before clinical symptoms emerge, if indeed the individual becomes symptomatic. The system can not only provide sentinel surveillance and other public health activities, but can facilitate research in disciplines such as immunology, virology, epidemiology, affective and cognitive neurobiology and health psychology. The aim and scope of this paper is to, within context, describe both the rationale and functional components and operation of this system in a variety of settings. The objective of the paper is to explicate both the operational characteristics of this approach and the multiple applications it may have in the disciplines identified above as well as primary health care and non-medical applications.