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Home  >  Medical Research Archives  >  Issue 149  > Inhibition and eradication of Streptococcus pyogenes biofilm by phytochemical extracts of cranberry and sumac berry
Published in the Medical Research Archives
Nov 2022 Issue

Inhibition and eradication of Streptococcus pyogenes biofilm by phytochemical extracts of cranberry and sumac berry

Published on Nov 28, 2022

DOI 

Abstract

 

Background: Diverse infections occur due to specific virulence factors of Streptococcus pyogenes, such as surface proteins and their biofilm formation capacity. This study aimed to assess the anti-biofilm effects of phytochemical-rich fruit extracts of cranberry (Vaccinium macrocarpon) and sumac berry (Rhus typhina).

Methods: Biofilm inhibition and eradication potential of the berries were tested by metabolic activity measurement and viable cell count technique as well as visualization using scanning electron microscopy (SEM).

Results: Minimum biofilm inhibitory concentration and minimum biofilm eradicating concentration of cranberry and sumac berry extracts ranged from 1 to >4 mg mL-1 and 2 to >16 mg mL-1, respectively. The effects of these extracts on the pre-formed biofilms and biofilm formation were imaged. The scanning electron microscopy images were indicative that the extracts could affect the integrity of bacteria hence quenching the biofilm formation capacity of S. pyogenes.

Conclusion: Further investigations on quorum sensing and exopolysaccharide formation can confirm the anti-biofilm potency of extracts.

Author info

H.p. Vasantha Rupasinghe, Soheila Abachi, Bruce Rathgeber, Song Lee

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