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Home  >  Medical Research Archives  >  Issue 149  > Cryptochrome: An ancient blue light photoreceptor impacts modern mammalian physiology
Published in the Medical Research Archives
Jan 2023 Issue

Cryptochrome: An ancient blue light photoreceptor impacts modern mammalian physiology

Published on Jan 31, 2023

DOI 

Abstract

 

Cryptochromes, evolutionally conserved and retained in mammals as transcriptional regulators having a repressive role in the transcription-translation feedback loop, the molecular mechanism behind the control of the endogenous mammalian circadian clock. This clock mechanism regulates the oscillation of a huge number of clock-controlled output genes. This in turn is responsible for modification of the physiological response of most organs and tissues, to coordinate with diurnal and seasonal changes in light and nutrient availability. Cryptochromes have also been found to participate in additional signalling cascades, outside of the circadian system, forming supplementary feedback loops that initiate cross-talk between systems influencing metabolism, inflammation and DNA damage response to maintain cellular homeostasis. This physiological organisation system has developed from Palaeolithic man but is still relevant in our modern world.

Author info

David Smith

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