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Cytomegalovirus (CMV)is a member of the Herpes viridae family, its seroprevalence is high in the general population. CMV infection in the immunocompromised is a serious, sometimes fatal complication that can affect several organs. For immunocompetent patients, this infection is usually pauci- or asymptomatic, which evolves spontaneously favorably and does not require specific treatment. However, the primary infection can be exceptionally serious with multivisceral involvement, for which antiviral treatment is indicated with generally a quickly favorable response. In this article, we present an unusual case of hepatitis and pancreatitis due to CMV in an immunocompetent patient.  The diagnosis was retained after excluding the most frequent and potential causes of acute hepatitis, with a brief review of the literature.