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Epilepsy is one of the common neurological disease affecting millions of people worldwide. Multiple class of antiepileptic drugs (AEDs) are available which makes it difficult to select an appropriate drug therapy for epilepsy. With introduction of newer generation of antiepileptics, the drug Pool has become wider. Factors which determine the selection of therapy includes seizure type, adverse effect, drug-drug interaction, age, pregnancy, cost of treatment and drug compliance. Though the older generation of antiepileptics were effective in controlling seizures, we found that newer generation of antiepileptics are gaining popularity among the prescriber. Reason for this shift being, better efficacy, fewer side effect and better compliance by the patients. We completed the study with the conclusion that newer antiepileptic especially levetiracetam, are more preferred by doctors in comparison with older antiepileptic drugs for control of seizures, though previous generation of antiepileptics has still role in management of epilepsy and individualistic approach is needed in choosing appropriate antiepileptics.