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Among the diseases of oral cavity, dental caries is the most common microbial diseases affecting the individual’s teeth globally along with the periodontal disease. There could be various reasons for the delay of the treatment for dental caries which includes socioeconomic status, lack of awareness about dental diseases and dental treatments. Life style habits also play a prominent role. Delay of dental caries treatment would lead to pulpitis. Here we present a case report of a 62-year-old male patient with chronic irreversible pulpitis in relation to 36. Patient had a history of smoking and chewing paan. After a month patient died due to septic shock. We also present a few case reports of pulpitis progressing to space infections. It has been documented in the literature that, individuals with systemic diseases such as diabetes mellitus, hypertension, cardiovascular disease etc are having highest morbidity and mortality due to dental sepsis. Along with case reports in this article, we are going to make a sincere effort to provide complications of pulpitis. Thus, it would help in educating general public, budding dentists and clinicians in spreading the awareness about pulpitis and its sequeale.