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In case of an acute infection of borreliosis, the best therapy is azithromycin 500 mg combined with cotrimoxazole 960 mg, 2x1 per day mostly over 10 days. For chronic and long-lasting infections rifampicin 450mg can be added. There is also a coinfection with babesia atovaquone combined with tinidazole that should be subsequently followed. In a long-lasting stadium of a neuroborreliosis with typical symptoms mostly combined with other bacterial and viral coinfections hydroxychloroquine and/or disulfiram are the best therapy. Whereas disulfiram inhibits P 450-cytochrome, fluconazole induces this elimination system so a combination with artemether is useful. Disulfiram penetrates all tissues, but also cytoplasm, nucleus, and mitochondria, and passes the blood-brain barrier. Cystic borrelia has a low and downregulated metabolism for a long period, you need a long time (about 18-21 months) to block the mechanism for energy supply (ATP) and replication. Homeopathic dispensing and plant extractions as well gamma-globulins are surely effective during chronic or relapse stadium.