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Home  >  Medical Research Archives  >  Issue 149  > Optic disc drusen: new hypotheses on systemic calcification
Published in the Medical Research Archives
Dec 2023 Issue

Optic disc drusen: new hypotheses on systemic calcification

Published on Dec 26, 2023




Optic disc drusen (ODD) are acellular calcified deposits within the optic nerve head. They arise early in life, usually remain asymptomatic with a benign prognosis, and they are most often clinically relevant as they can be mistaken for papilloedema, can result in asymptomatic optic nerve thinning resembling glaucoma, or can have complications such as anterior ischaemic optic neuropathy with sudden loss of vision. There is still a lot of uncertainty about the pathogenesis of ODD, and prognostic factors for vision loss in the long term. The strongest association of ODD is with pseudoxanthoma elasticum, a condition of systemic ectopic calcification. Understanding the shared biochemical pathways underlying pseudoxanthoma elasticum and other conditions with the same phenotype, highlights pyrophosphate as an important factor in ectopic calcification and a potential therapy.

Author info

Jesse Gale, Yuanzhang Jiao

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