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Home  >  Medical Research Archives  >  Issue 149  > Continuous Glucose Monitoring Variables and HbA1c in Children and Adolescents with Type 1 Diabetes
Published in the Medical Research Archives
Jan 2024 Issue

Continuous Glucose Monitoring Variables and HbA1c in Children and Adolescents with Type 1 Diabetes

Published on Jan 02, 2024




Objective: Associations between Continious Glucose Monitoring (CGM) variables (metrics) and HbA1c is not well understood. In this exploratory study we assessed the association between mean sensor glucose (mean CGM) and HbA1c and how it is affected by sensor type (real-time CGM vs. intermittent scanned CGM), patient characteristics, and other CGM variables in children and adolescents with type 1 diabetes.

Methods: Data were obtained from Swedish paediatric diabetes quality registry (SWEDIABKID) and Diasend. Paired HbA1c and CGM data collected within one year were analyzed, including a maximum of four individual HbA1c at least 2 months apart and for which CGM data were available for 12 weeks prior to HbA1c.

Results: 174 children were included of whom 141 had a diabetes duration ≥ 1-year; 71 used real-time CGM and 70 used intermittent scanned CGM. The intermittent scanned CGM children were older, had a higher proportion of children on insulin injections versus pump, and more CGM recordings during an 8-week registration. A stronger correlation between HbA1c and mean CGM was observed based on a sensor period ≥ 8 weeks preceding HbA1c in children with ≥ 1-year diabetes duration (r= 0.70, p<0.01). HbA1c was more weakly correlated with Time In Range (r=-0.40, p<0.01). Low HbA1c and low CGM Standard Deviation and, for intermittent scanned CGM, higher daily sensor duration was associated with a stronger correlation between mean CGM and HbA1c. HbA1c was dependent on Time Above Range and Time Below Range in intermittent scanned CGM users while in real-time CGM only Time Above Range impacted.

Conclusions: HbA1c correlated only moderately with mean CGM and discrepancies should be expected for the child with short diabetes duration, high HbA1c or high CGM Standard Deviation.

Author info

Peter Bang, Baraa Al-taie, Ulf Samuelsson

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