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Home  >  Medical Research Archives  >  Issue 149  > Specific Mutations Identified in Patients Vaccinated and Infected with COVID-19 in Senegal
Published in the Medical Research Archives
Mar 2024 Issue

Specific Mutations Identified in Patients Vaccinated and Infected with COVID-19 in Senegal

Published on Mar 01, 2024




Background: Vaccination against SARS-CoV-2 is currently the best preventive measure to control the COVID-19 pandemic. However, in some cases, it appeared that despite the vaccination, some people were reinfected.

Aim: The objective of this study is to monitor preliminary data of COVID-19 reinfection cases in vaccinated individuals in Senegal.

Methods: In this study, we used the Oxford Nanopore MinION portable sequencer as detailed in the ARTIC network to test SARS-CoV-2 positive samples from reinfected patients. A total of 71 subjects were monitored with 37 vaccinated patients and 34 non-vaccinated and samples were sequenced in genomic platform at IRESSEF.

Results: We noted the presence of three major lineages B.1.617.2, AY4 and AY34 in vaccinated people. In addition, the mutation W152R and two other mutations never described (T1136S and V1137L) were found in tested genomic sequences.

Conclusion: These results will contribute to monitor future epidemics and to control the effectiveness of the vaccination against COVID-19 especially the Variant of Concern and allow us to improve surveillance for COVID-19 pandemic.

Author info

Abdou Padane, Cyrille Diedhiou, Marièma Sarr, Seyni Ndiaye, Abdoulaye Souaré, Mame Diop, Marilyne Aza-gnandji, Ndèye Diagne, Khadim Gueye, Nafissatou Leye, Ndèye Diouf, Mame Ndiaye, Ndèye Dabo, Ndèye Sow, Djibril Wade, Djibril Wade, Souadou Ndoye, Abdoul Diallo, Anna Ndiaye, Yacine Dia, Gora Lo, Abdoulaye Diallo, Ousmane Diop, Aminata Mboup, Ambroise Ahouidi, Papa Diaw, Badara Cissé, Moustapha Mbow, Makhtar Camara, Ndéye Kane, Souleymane Mboup

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