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Background: Chronic kidney disease (CKD) is considered a major public health issue, not only due to the possibility of progressing to end-stage renal disease but also because it is closely related to the development of acute coronary syndrome (ACS). It is still unclear in the literature whether individuals with renal dysfunction present particularities in the clinical manifestations during acute myocardial infarction, similar to individuals with diabetes.

Aims: To evaluate the characteristics of clinical manifestations in patients with CKD and ACS.

Methods: The Chi-square test and Student's t-test were used to analyze the profile of patients with coronary syndrome and renal disease who were admitted for chest pain at the analyzed hospital. Results: The majority of individuals with renal disfunction present highly suspicious characteristics, with statistical significance by presenting a p-value equal to 0.01 and a 95% confidence interval (0.04-0.14). Conclusion: Individuals with kidney disease predominantly exhibit highly suspicious clinical manifestations for acute coronay syndrome.