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Radiopharmaceutical therapy directly targets radioactive drugs to cancer cells. Incorporating radiopharmaceutical therapy requires quantitative assessment of the radiation dose delivered to the cancer cells and surrounding normal tissue(s). This paper discusses the necessity of tumor and normal tissue dosimetry processes in radiopharmaceutical therapy and strategies to align this therapy within a patient’s care plan. We discuss a process to manage radiopharmaceutical therapy within institutions to ensure dose metrics can be incorporated into the care plan for review by participants in patient care.