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Mosquitoes are the most harmful insects that cause 2 million illnesses and kill 28,000 people daily, mostly in underdeveloped countries.^[1],[2] Their environment is like that of the Panama Canal. During its construction, mosquito control measures successfully reduced yellow fever and malaria to zero.^[3] The challenge for researchers is to replicate these results in hard-hit regions. To do so, they must produce an achievable road map for communities to follow. In this study we analyze the lessons of the past, recommend the same or alternative measures based on today’s technology and knowledge base, and present experiments to support their effectiveness.