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High-flow nasal oxygen therapy (HFO) is a device that supplies warmed and humidified inspiratory gas through a nasal cannula at higher flow rates than conventional oxygen therapy, with an inspired oxygen fraction that can fluctuate from 21% to 100%. The primary aim of our study is to compare the efficacy of ONHD versus face mask. This trial was an experimental cohort study carried out at the Central Block of the Ibn Rochd University Hospital in Casablanca, over a period of three months, and involved 40 patients distributed into two groups: the face mask PO group (n=20) and the ONHD PO group (n=20). We evaluated apnea time without desaturation (SPO2˃95%), mean SPO2 during pre-oxygenation and apnea time, ETCO2 value after intubation and the frequency of complications during pre-oxygenation, The results show that ONHD compared with the face mask prolongs the duration of apnea without desaturation (SPO2˃95%), especially in high-risk patients, especially obese individuals.