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Medial tibial stress syndrome, sometimes referred to as shin splints, is an overuse injury of the lower extremities. It is commonly managed conservatively, but there is lack of consensus on the application of new treatment options such as regional dextrose 5% injections in regional superficial fascia. Over the last decade, regional dextrose 5% injections are popular for the treatment of orthopedic complaints and sports injuries because of easy application, low cost and excellent safety profile. This article describes a 25-year-old runner suffering from pain in both shins for several years. His pain level went from 7/10 to 0/10 after three sessions of dextrose 5% injections in the superficial fascia, and he recovered permanently after five sessions. This case report is an invitation to design more studies to confirm whether this novel approach may become one of the new tools for athletes suffering from shin splints.