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ABSTRACTS

The mechanistic pathway for the antioxidant efficacy of the aqueous Moringa oleifera seed extract in gestational diabetes was investigated by evaluating five  antioxidant parameters, three (MDA,GSH and GST) of which were done from the uterus and two (CAT  and SOD) from the serum using a pregnant diabetic animal model. Pregnant Wistar rats were divided into four groups of 8 each made up of Normal control untreated, Non-diabetic treated, Diabetic treated and  Diabetic untreated. The four groups of animals were used to evaluate the effect of the extract on the biochemical parameters and the level of antioxidants in the uterus and the serum. The level of significance of the level of biochemical parameters were determined respectively using the Analysis of variance(ANOVA).

The administration of 300mg/kg body weight of Moringa oleifera seed extract produced significant increase in Catalase and SOD levels in the serum. However, there was a significant decrease in the uterus of MDA and a significant increase in the uterus of GSH and GST when compared with the normal untreated group and the untreated diabetic groups.

These observations support the hypothesis that aqueous Moringa oleifera seed extract possesses antioxidant parameters that are able to counter or revert the effect of gestational diabetes induced by oxidative stress.