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The combination of French maritime pine bark extract (Pycnogenol^®), aminoacids and roburin (Prelox^®) was tested in a randomized, double-blind, placebo-controlled, cross over study with 50 infertile men. Primary outcome of the study was the improvement of sperm quantity and quality, results have been already published.

Secondary outcome of the study were monitoring of testosterone levels and blood pressure.

Testosterone levels increased significantly (p<0.001) following intake of Prelox^®. The slightly elevated blood pressure of the participants was lowered to normal values after treatment.