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Low-grade myofibroblastic sarcoma (L-G MFS) is a rare tumour that commonly affects the soft tissues of the head and neck. Its location in bone is very rare and there are few cases published in the literature, which sometimes leads to a wrong initial diagnosis.  The following report will give an overview of the clinical, radiological and histological findings in two patients with a very unusual bone sarcoma, which are more often found in the soft tissues. Treatment options and outcome will be discussed.

On excision of any sarcoma tumor, surgeons should be aware of the potential risk for erroneous management of malignancy. If not, careless surgery may render the treatment protocol complicated and additional bed tumor resection with poor function and prognosis.

Low-grade myofibroblastic sarcoma (L-G MFS) requires a wide resection to avoid local recurrence and distant metastases.

We present two cases with an initial diagnosis of giant cell tumor and fibrous dysplasia respectively, which were diagnosed as low-grade bone myofibroblastic sarcoma after clinical, radiological y pathological studies.